Potic, Jelena (55293803000)Jelena (55293803000)PoticBergin, Ciara (24178646600)Ciara (24178646600)BerginGiacuzzo, Clarice (57200127516)Clarice (57200127516)GiacuzzoDaruich, Alejandra (55362251100)Alejandra (55362251100)DaruichPournaras, Jean-Antoine (8506622000)Jean-Antoine (8506622000)PournarasKowalczuk, Laura (26430999000)Laura (26430999000)KowalczukBehar-Cohen, Francine (7005808435)Francine (7005808435)Behar-CohenKonstantinidis, Lazaros (14039078900)Lazaros (14039078900)KonstantinidisWolfensberger, Thomas J. (7004757176)Thomas J. (7004757176)Wolfensberger2025-06-122025-06-122020https://doi.org/10.1097/IAE.0000000000002378https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078313364&doi=10.1097%2fIAE.0000000000002378&partnerID=40&md5=9806715ab74c37db3f2aa9934c46f225https://remedy.med.bg.ac.rs/handle/123456789/5052Purpose:To quantify changes in photoreceptor density using adaptive optics fundus camera in patients after retinal detachment (RD) and to correlate them with macular involvement and best-corrected visual acuity.Methods:At 1 and 3 months (M1 and M3) after vitrectomy, 194 patients underwent adaptive optics imagery in both eyes, at 5 locations, that we matched between time points using anatomical landmarks. Twenty-two patients (10 fovea-OFF [OFF] and 12 fovea-ON [ON]) had matched and analyzable adaptive optics images. We used analysis of variance for repeated measures.Results:Best-corrected visual acuity (logarithm of the minimum angle of resolution and Snellen equivalent [SE]) was significantly different between OFF and ON RDs at baseline: 2.0 (2.3-0.95) (SE: 20/2000) versus 0 (0.1-0) (SE: 20/20); at M1: 0.35 (0.5-0.1) (SE: 20/40) versus 0.05 (0-0.1) (SE: 20/25); and at M3: 0.25 (0.3-0.1) (SE: 20/32) versus 0 (0-0) (SE: 20/20). We observed that cone density was stable in fellow eyes between M1 and M3 (P = 0.67); decreased in treated eyes than in fellow eyes (P < 0.05); and increased postoperatively in the ON group (P = 0.02) but not in the OFF group (P = 0.97). Visual acuity and RD type were independently correlated with cone density (P = 0.004, P = 0.000).Conclusion:Postoperative cone density was reduced in OFF RD, but also in the ON group, although the drop recovered during the 3-month follow-up. Cone density was significantly correlated with both visual acuity and type of RD at both time points. Copyright © by Ophthalmic Communications Society, Inc.adaptive opticscone mosaiccone topographyintereye differenceretinal detachmentvitrectomy