Lekić, Branislav (56092444000)Branislav (56092444000)LekićGajić-Veljić, Mirjana (24767639800)Mirjana (24767639800)Gajić-VeljićBonači-Nikolić, Branka (10839652200)Branka (10839652200)Bonači-NikolićNikolić, Miloš (56910382000)Miloš (56910382000)Nikolić2025-06-122025-06-122019https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065390296&partnerID=40&md5=c88576ab35ff0a556a65ebc64ddb0219https://remedy.med.bg.ac.rs/handle/123456789/5871Cutaneous necrotizing eosinophilic vasculitis (CNEV) is a rare type of vasculitis. Eosinophilic vasculitis is a necrotizing vasculitis with eosinophilic vascular infiltration, in which eosinophils mediate vascular damage in the disease process. We present a case of an 18-year-old girl who developed palpable purpura and hemorrhagic bul-lae over the lower extremities associated with itching, 7 days after the commencement of penicillin therapy. Plasma cryofibrinogen was positive. Histopathology showed an infiltration of eosinophils within and around the vessel walls and a complete absence of nuclear dust and neutrophils. Oral prednisone at 1 mg/kg induced remission in 2 weeks; the prednisone dose was tapered and discontinued after 2.5 months. There was no evidence of recurrence after 37 months of follow-up. Our patient represents a rare case of drug/penicillin-induced CNEV associated with cryofibrinogenemia, without systemic organ involvement. © 2019, Croatian Dermatovenerological Society. All rights reserved.CryofibrinogenemiaCutaneous necrotizing eosinophilic vasculitisDrug-inducedPenicillin