Aljančić, Ivana S. (6602458297)Ivana S. (6602458297)AljančićPešić, Milica (36768679400)Milica (36768679400)PešićMilosavljević, Slobodan M. (7006371741)Slobodan M. (7006371741)MilosavljevićTodorović, Nina M. (6701783678)Nina M. (6701783678)TodorovićJadranin, Milka (15725185100)Milka (15725185100)JadraninMilosavljević, Goran (53865455700)Goran (53865455700)MilosavljevićPovrenović, Dragan (6506406092)Dragan (6506406092)PovrenovićBanković, Jasna (24278374400)Jasna (24278374400)BankovićTanić, Nikola (7801574805)Nikola (7801574805)TanićMarković, Ivanka D. (7004033826)Ivanka D. (7004033826)MarkovićRuždijić, Sabera (7003935669)Sabera (7003935669)RuždijićVajs, Vlatka E. (35508693900)Vlatka E. (35508693900)VajsTešević, Vele V. (6602440793)Vele V. (6602440793)Tešević2025-06-122025-06-122011https://doi.org/10.1021/np200241chttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79960728011&doi=10.1021%2fnp200241c&partnerID=40&md5=0e66e9f06d2a47ba4233a3830c0ec72ehttps://remedy.med.bg.ac.rs/handle/123456789/10027From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multi-drug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport. © 2011 The American Chemical Society and American Society of Pharmacognosy.