Kontic, Milica (43761339600)Milica (43761339600)KonticRadovanovic, Sanja (56432618100)Sanja (56432618100)RadovanovicNikolic, Milos (56910382000)Milos (56910382000)NikolicBonaci-Nikolic, Branka (10839652200)Branka (10839652200)Bonaci-Nikolic2025-06-122025-06-122012https://doi.org/10.1159/000337944https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865009842&doi=10.1159%2f000337944&partnerID=40&md5=611885312211ce00a717907646a2d91ehttps://remedy.med.bg.ac.rs/handle/123456789/9620Objective: To report the first case of concomitant drug-and infection-induced antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) in a patient treated with propylthiouracil (PTU) and suffering from tuberculosis. Presentation and Intervention: A 28-year-old woman with PTU-treated hyperthyroidism presented with fever, purpura, pulmonary cavitations and ANCA to myeloperoxidase, bactericidal/permeability-increasing protein (BPI), proteinase-3 and elastase. Skin histopathology confirmed vasculitis. However, sputum examination revealed Mycobacterium tuberculosis. Remission was achieved after PTU withdrawal and treatment with antituberculosis drugs. Conclusion: Our case confirmed that BPI-ANCA are elevated in active tuberculosis. Multispecific ANCA were helpful for the diagnosis of concomitant PTU-and M. tuberculosis-induced AAV. Copyright © 2012 S. Karger AG, Basel.Antineutrophil cytoplasmic autoantibodiesBactericidal/permeability-increasing proteinDrug-induced vasculitisPropylthiouracilTuberculosis