Djordjevic, Stefan A. (57192951203)Stefan A. (57192951203)DjordjevicMilic-Rasic, Vedrana (6507653181)Vedrana (6507653181)Milic-RasicBrankovic, Vesna (57192421308)Vesna (57192421308)BrankovicKosac, Ana (55786067800)Ana (55786067800)KosacDejanovic-Djordjevic, Ivana (57222274556)Ivana (57222274556)Dejanovic-DjordjevicMarkovic-Denic, Ljiljana (55944510900)Ljiljana (55944510900)Markovic-DenicDjuricic, Goran (59157834100)Goran (59157834100)DjuricicMilcanovic, Natasa (57205172234)Natasa (57205172234)MilcanovicKovacevic, Smiljka (57222277313)Smiljka (57222277313)KovacevicPetrovic, Hristina (57222276058)Hristina (57222276058)PetrovicDjukic, Milan (23988377500)Milan (23988377500)DjukicZdravkovic, Vera (6603371560)Vera (6603371560)Zdravkovic2025-07-022025-07-022021https://doi.org/10.1016/j.nmd.2021.02.002https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102141082&doi=10.1016%2fj.nmd.2021.02.002&partnerID=40&md5=ce94d0f8aa2713e236e8a2db7a9dfeedhttps://remedy.med.bg.ac.rs/handle/123456789/12326We aimed to estimate the prevalence of glucose and lipid metabolism disorders in children and adolescents with spinal muscular atrophy (SMA) types 2 and 3. A cross-sectional study was conducted. Medical history, anthropometric measurements, pubertal status, blood chemistry (glucose and insulin levels, lipid profile, aminotransferases, and hemoglobin A1c [HbA1c]), and liver ultrasound were obtained in all patients. Oral glucose tolerance test was performed in those with body mass index (BMI) >25th percentile or glucose or HbA1c levels in the prediabetic range. A total of 37 patients with SMA (22 type 2, 15 type 3) with a median age of 8.5 years (range 2–18.9 years) were included. Eleven patients (29.7%) met the criteria for prediabetes, but none had overt type 2 diabetes. Dyslipidemia was detected in 11 patients (29.7%), and 4 (10.8%) had hepatic steatosis on ultrasound. Sixteen patients (43.2%) had at least one abnormal finding (prediabetes, dyslipidemia, or hepatic steatosis); all but one were non-ambulatory and 12 (75%) had BMI ≥85th percentile. One young child developed fasting hypoglycemia. Our results suggest that non-ambulatory overweight/obese SMA patients are particularly prone to abnormalities in glucose and lipid metabolism. Young underweight patients might develop fasting hypoglycemia. © 2021 Elsevier B.V.Blood glucoseDyslipidemiasFatty liverInsulin resistanceOral glucose tolerance testSpinal muscular atrophy