Balac, I. (55190020400)I. (55190020400)BalacJurisic, Vladimir (6603015144)Vladimir (6603015144)JurisicLaban, A. (55189150900)A. (55189150900)LabanRandelovic, T. (23499133300)T. (23499133300)RandelovicKnezevic, P. (55189227600)P. (55189227600)KnezevicPantic, I. (36703123600)I. (36703123600)PanticDzodic, R. (6602410321)R. (6602410321)Dzodic2025-06-122025-06-122012https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859813436&partnerID=40&md5=ac5fe72914fb9524eb5470d8339aa96bhttps://remedy.med.bg.ac.rs/handle/123456789/9801Purpose: To investigate the influence of the angiogenesis parameter CD34 microvascular density (MVD) on overall survival of colorectal cancer (CRC) patients. Methods: Thirty-one CRC patients were followed-up for 72 months after curative colorectal operation. Blood vessels measurement was done using the CD34-MVD immunochemistry method, and light microscopy. Results: MVD was inversely correlated with patients' survival. MVD value < 35 proved as independent good prognostic factor, and patients with this value lived during the 72-month follow up after surgery, while a MVD value > 65 was an independent poor prognostic factor and such patients died within 11 months after radical surgery for CRC (p<0.01). Conclusion: According to these results, the CD34-MVD seems to be a significant prognosticator of overall survival in CRC patients. © 2012 Zerbinis Medical Publications.AngiogenesisCD34Colorectal cancerMicrovascular densitySurvival