The Effect of α-lipoic Acid on C-Reactive Protein Level: A Meta-analysis of Randomized, Double-Blind, and Placebo-Controlled Studies

Đukić, Ljiljana (6506225276)Ljiljana (6506225276)ĐukićTrajković, Lazar (57915038300)Lazar (57915038300)TrajkovićKnežević, Tamara (25635620100)Tamara (25635620100)KneževićDimitrijević, Jelena (57189212145)Jelena (57189212145)DimitrijevićKrstić, Danijela (57199836500)Danijela (57199836500)KrstićStojanović, Marko (56817075100)Marko (56817075100)Stojanović2025-06-122025-06-122022https://doi.org/10.1177/15593258221126827https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139254690&doi=10.1177%2f15593258221126827&partnerID=40&md5=abe27e90805b57baad7cd97b946ccf13https://remedy.med.bg.ac.rs/handle/123456789/3361The C-reactive protein is generally considered a marker of inflammation, and it is widely used in clinical practice as a minimally invasive index of any ongoing inflammatory response. Alpha-lipoic acid (ALA) supplementation can be beneficial for human health, especially in the sense of its anti-inflammatory action. The aim of this meta-analysis was to, based on the currently available highest level of evidence (prospective, randomized, double-blind, and placebo-controlled data), investigate the effect of ALA supplementation on CRP levels. Prospective, randomized, double-blind, and placebo-controlled clinical trials were extracted after a systematic search of PubMed, the Cochrane Library, the Web of Science, EMBASE, and the Scopus databases. A random effect model was used in this meta-analysis to investigate the influence of ALA on the blood CRP level. The subgroup analysis and meta-regression were used to identify the source of heterogeneity. This meta-analysis provided evidence of the positive effect of ALA on the reduction of the blood CRP level. The subgroup analysis and meta-regression results indicated that ALA can reduce the CRP level when administrated at a 600 mg dose, and not in higher or lower doses. Also, a shorter duration of study positively correlates with the reduction of CRP after ALA supplementation. © The Author(s) 2022.alpha-lipoic acidC-reactive proteindose-dependent effectduration-dependent effectmeta-analysisThe Effect of α-lipoic Acid on C-Reactive Protein Level: A Meta-analysis of Randomized, Double-Blind, and Placebo-Controlled Studies