Pekmezovic, Tatjana (7003989932)Tatjana (7003989932)PekmezovicSvetel, Marina (6701477867)Marina (6701477867)SvetelMaric, Jelena (6602218323)Jelena (6602218323)MaricDujmovic-Basuroski, Irena (6701590899)Irena (6701590899)Dujmovic-BasuroskiDragasevic, Natasa (59157743200)Natasa (59157743200)DragasevicKeckarevic, Milica (18434375900)Milica (18434375900)KeckarevicRomac, Stanka (7003983993)Stanka (7003983993)RomacKostic, Vladimir S. (35239923400)Vladimir S. (35239923400)Kostic2025-06-132025-06-132007https://doi.org/10.1007/s10654-007-9157-7https://www.scopus.com/inward/record.uri?eid=2-s2.0-34547651414&doi=10.1007%2fs10654-007-9157-7&partnerID=40&md5=39ebe13868d616cb40c9fb9e0e98e14chttps://remedy.med.bg.ac.rs/handle/123456789/10846The objective of this study was to estimate probability of survival of Huntington's disease (HD) patients in Serbia as a function of CAG repeat length and selected demographic variables. This follow-up study was carried out at the Institute of Neurology, Clinical Centre of Serbia, Belgrade, 1982-2004. The study group consisted of 112 HD patients. The significant inverse correlation was found between CAG repeat length and age at onset of HD (r = -0.732, P = 0.001) and age at death (r = -0.760, P = 0.001). The cumulative probabilities of survival in a five, ten, fifteen, and twenty-years' period were 90.9, 63.2, 10.3 and 4.5%, respectively. Higher survival probabilities were registered in female patients, as well as in those with older age at onset and lower number of CAG repeat length (≤46). The Cox regression analysis showed that significantly poorer outcome of HD in our population was related to younger age at onset (HR-hazard ratio = 1.9; P = 0.047), and larger CAG numbers (HR = 2.4; P = 0.071). The female sex was statistically significantly associated with longer survival (HR = 0.4; P = 0.007). These data might be of some importance for further exploration of natural history and prognosis of HD. © 2007 Springer Science+Business Media B.V.AgeCAG repeat lengthFemale sexHuntington's diseasePrognosisSurvival