Dragović, Gordana (23396934400)Gordana (23396934400)DragovićSumarac-Dumanovic, Mirjana (7801558773)Mirjana (7801558773)Sumarac-DumanovicKhawla, Al Musalhi (57193262910)Al Musalhi (57193262910)KhawlaSoldatović, Ivan (35389846900)Ivan (35389846900)SoldatovićAndjić, Mladen (57725550500)Mladen (57725550500)AndjićJevtović, Djordje (55410443900)Djordje (55410443900)JevtovićNair, Devaki (7005754649)Devaki (7005754649)Nair2025-06-122025-06-122018https://doi.org/10.1016/j.yexmp.2018.06.004https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049343472&doi=10.1016%2fj.yexmp.2018.06.004&partnerID=40&md5=6c9bad4b9fb084e0b1c41279de1a1216https://remedy.med.bg.ac.rs/handle/123456789/6198Background: Data about correlation of interleukins (IL-1 α IL-1 β IFN γ IL-2, IL-4, IL-6, IL-8, IL-10), adipocytokines (leptin, adiponectin, monocyte chemoattractant protein-1 (MCP-1), resistin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor alpha (TNFα), ferritin, C reactive protein (CRP) and vascular endothelial growth factor (VEGF) with homeostasis model assessment (HOMA) in HIV/AIDS patients are still limited. Therefore the aim of this study was to evaluate the possible correlations of serum levels of PAI-1, leptin and ferritin with HOMA in HIV/AIDS patients treated with combined antiretroviral therapy (cART). Methods: This cross-sectional study included 64 HIV/AIDS patients, all Caucasians, receiving cART at the HIV/AIDS Centre, Belgrade, Serbia. PAI-1, leptin, ferritin and insulin levels were measured using the Metabolic Syndrome Array I (Randox Laboratories Ltd., London, UK), while adiponectin and resistin levels were measured using Metabolic Syndrome Array II (Randox Laboratories Ltd., London, UK), interleukins (IL-1 α IL-1 β IFN γ IL-2, IL-4, IL-6, IL-8, IL-10), MCP-1, TNF-α as well as VEGF was measured using Cytokine Array I (Randox Laboratories Ltd., London, UK). Insulin resistance was determined using the homeostasis model assessment index (HOMA). Multicollinearity of independent variables in multivariate model was analyzed using Variance Inflation Factor. Results: Correlation analysis revealed significant correlations between HOMA and waist circumference, body mass index, patients’ age, number of cART combinations and triglycerides (p = 0.001, p = 0.001, p = 0.050, p = 0.044, p = 0.002, respectively). HOMA negatively correlated with levels of high density lipoprotein (HDL) (Rho = −0.282; p = 0.025). PAI-1 (Rho = 0.334; p= 0.007) and leptin (Rho = 0.492; p = 0.001) together with ferritin (Rho = 0.396, p = 0.001) positively and significantly correlated with HOMA. Levels of IL-1 α IL-1 β IFN γ IL-2, IL-4, IL-6, IL-8, IL-10, adiponectin, MCP-1, resistin, TNF-α CRP and VEGF did not significantly correlate with HOMA. Further, multiple logistic regression showed that there is a statistically significant correlation between PAI, leptin and ferritin with HOMA levels (p = 0.042; p < 0.001, p = 0.009). Conclusions: We showed significant correlation between PAI-1, leptin and ferritin, independently of each other with HOMA, in HIV/AIDS patients on cART. © 2018 Elsevier Inc.FerritinHIV/AIDS patientsHOMALeptinPAI-1