Milenković, Svetlana J. (57210676212)Svetlana J. (57210676212)MilenkovićMirković, Ljiljana B. (23474551800)Ljiljana B. (23474551800)MirkovićJovandarić, Miljana Z. (56748058300)Miljana Z. (56748058300)JovandarićMilenković, Dušan M. (58422958000)Dušan M. (58422958000)MilenkovićBanković, Violeta V. (57193992907)Violeta V. (57193992907)BankovićJanković, Borisav Z. (7005898688)Borisav Z. (7005898688)Janković2025-06-122025-06-122017https://doi.org/10.1515/jpem-2016-0352https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029668013&doi=10.1515%2fjpem-2016-0352&partnerID=40&md5=1b2b3747bc327c9e4a68ab64f7f46500https://remedy.med.bg.ac.rs/handle/123456789/7220Insulin resistance (IR) in adults has been associated with intrauterine growth restriction (IUGR). Leptin and adiponectin correlations with anthropometric parameters and IR at 72 h in discordant twins were tested. We included 24 discordant (birth weight discordance ≥20% in relation to the heavier cotwin) and 30 concordant (birth weight discordance ≤10%) twins. A correlation between leptin (but not adiponectin) level and birth weight (BW), birth length and head circumference in IUGR twins was recorded (p<0.05). Insulin sensitivity (IS) and homeostatic model assessment (HOMA)-IR in IUGR twins were similar to appropriate-for-gestational-age cotwins and unrelated to adipokines. In IUGR twins, adiponectin and insulin associated positively. In larger concordant twins' leptin level correlated with HOMA-IR and insulin. Leptin, but not adiponectin, levels correlate positively with anthropometric parameters in IUGR twins. IR in IUGR twins is unrelated to adipokines in the first few days of life. © 2017 2017 Walter de Gruyter GmbH, Berlin/Boston.adiponectinfetal programminginsulin sensitivity (IS)intrauterine growth restriction (IUGR)leptintwins