Milojevic, Bogomir (36990126400)Bogomir (36990126400)MilojevicDjokic, Milan (15019194000)Milan (15019194000)DjokicSipetic-Grujicic, Sandra (6701802171)Sandra (6701802171)Sipetic-GrujicicMilenkovic-Petronic, Dragica (24923372100)Dragica (24923372100)Milenkovic-PetronicVuksanovic, Aleksandar (6602999284)Aleksandar (6602999284)VuksanovicDragicevic, Dejan (6506794751)Dejan (6506794751)DragicevicBumbasirevic, Uros (36990205400)Uros (36990205400)BumbasirevicTulic, Cane (6602213245)Cane (6602213245)Tulic2025-06-122025-06-122011https://doi.org/10.1007/s11255-011-9902-4https://www.scopus.com/inward/record.uri?eid=2-s2.0-80555155625&doi=10.1007%2fs11255-011-9902-4&partnerID=40&md5=923e77033d2903afb3ea25460dda5dc2https://remedy.med.bg.ac.rs/handle/123456789/10011Objective To identify independent risk factors for the development of bladder cancer after surgical management of upper urinary tract transitional cell carcinoma (UUT-TCC). Patients and methods Between January 1999 and December 2008, 154 patients were treated surgically for UUT-TCC at the Clinic of Urology, Clinical Center of Serbia. Patients with a previous history of bladder cancer and patients with concomitant bladder cancer were excluded from the study. In all, 92 patients were then available for evaluation. The median follow-up after surgery was 39.5 months. Univariate and multivariate analyses using the logistic regression model were performed. The intravesical disease-free rate and survival were calculated using the Kaplan-Meier method, and the log-rank test was used to determine statistical differences. Results and limitations In this study, 21.7% patients treated for UUT-TCC developed subsequent bladder tumors. Tumor multifocality was the only independent predictor associated with the development of subsequent bladder cancer (P = 0.028, RR = 3.52). Intravesical recurrence-free survival rates for these 92 patients at 1, 3, 5, and 7 years were 85.8, 80, 79.3, and 78.3%, respectively. Patients with tumors extending to multiple sites were significantly more likely to present subsequent intravesical recurrence (P = 0.006). The development of bladder cancer had no significant effect on the survival of patients who underwent surgical treatment of UUT-TCC, compared to patients without bladder cancer development (P = 0.660). Neither did the type of surgery mode affect patient survival (P = 0.245). This study is limited by biases associated with its retrospective design. Conclusion The multiplicity of the UUT-TCC is an independent risk factor for the occurrence of bladder cancer. © Springer Science+Business Media, B.V. 2011.Intravesical recurrencePredictive factorsSurvivalTransitional cell carcinomaUpper urinary tract