Redzic, Zoran B. (6602453895)Zoran B. (6602453895)RedzicIsakovic, Aleksandra (57202555421)Aleksandra (57202555421)IsakovicSegal, Malcolm B. (7201773258)Malcolm B. (7201773258)SegalThomas, Sarah A. (55268048900)Sarah A. (55268048900)ThomasRakic, Ljubisa M. (35580670800)Ljubisa M. (35580670800)Rakic2025-07-022025-07-022001https://doi.org/10.1016/S0006-8993(01)02115-1https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035957776&doi=10.1016%2fS0006-8993%2801%2902115-1&partnerID=40&md5=6d5067a91f1ef0e14803efbf27a49f78https://remedy.med.bg.ac.rs/handle/123456789/14510The brain efflux of radiolabelled hypoxanthine in the rat was rapid in the first minute after injection [Keff(i)=0.21±0.06 min-1], which was saturable with a Vmax=13.08±0.81 nM min-1 g-1, and a high Km.app (67.2±13.4 μM); the Ki.app for inosine was 31.5±7.6 μM. Capillary depletion analysis indicated that hypoxanthine accumulates in neurons and glia with the time. From cross-inhibition studies with different purines and pyrimidines, it suggests that these molecules could also be important substrates for this carrier. © 2001 Elsevier Science B.V.Blood-brain barrierBrain effluxBrain efflux indexHypoxanthineNucleobase