Savic, Lidija (16507811000)Lidija (16507811000)SavicMrdovic, Igor (10140828000)Igor (10140828000)MrdovicAsanin, Milika (8603366900)Milika (8603366900)AsaninStankovic, Sanja (7005216636)Sanja (7005216636)StankovicLasica, Ratko (14631892300)Ratko (14631892300)LasicaKrljanac, Gordana (8947929900)Gordana (8947929900)KrljanacSimic, Damjan (58010380500)Damjan (58010380500)SimicMatic, Dragan (25959220100)Dragan (25959220100)Matic2025-06-122025-06-122024https://doi.org/10.3390/jpm14060591https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196907835&doi=10.3390%2fjpm14060591&partnerID=40&md5=aaa6153667a3726b0b6c02b92bde9e6ehttps://remedy.med.bg.ac.rs/handle/123456789/1072Background: stress hyperglicemia (SH) is common in patients with ST-elevation myocardial infraction (STEMI). The aims of this study were to analyze the impact of SH on the incidence of all-cause mortality and major adverse cardiovascular events (MACE-cardiovascular death, nonfatal reinfarction, target vessel revascularization, and stroke) in STEMI patients without diabetes mellitus (DM) who have been treated successfully with primary PCI (pPCI). Method: we analyzed 2362 STEMI patients treated with successful pPCI (post-procedural flow TIMI = 3) and without DM and cardiogenic shock at admission. Stress hyperglycemia was defined as plasma glucose level above 7.8 mmol/L at admission. The follow-up period was 8 years. Results: incidence of SH was 26.9%. Eight-year all-cause mortality and MACE rates were significantly higher in patients with SH, as compared to patients without SH (9.7% vs. 4.2%, p < 0.001, and 15.7% vs. 9.4%, p < 0.001). SH was an independent predictor of short- and long-term all-cause mortality (HR 2.19, 95%CI 1.16–4.18, and HR 1.99, 95%CI 1.03–3.85) and MACE (HR 1.49, 95%CI 1.03–2.03, and HR 1.35, 95%CI 1.03–1.89). Conclusion: despite successful revascularization, SH at admission was an independent predictor of short-term and long-term (up to eight years) all-cause mortality and MACE, but its negative prognostic impact was stronger in short-term follow-up. © 2024 by the authors.myocardial infarctionprognosisstress hyperglycemia