Mut, Fernando (57060152100)Fernando (57060152100)MutGiubbini, Raffaele (7004319496)Raffaele (7004319496)GiubbiniVitola, Joao (6602072314)Joao (6602072314)VitolaLusa, Lara (8948006000)Lara (8948006000)LusaSobic-Saranovic, Dragana (57202567582)Dragana (57202567582)Sobic-SaranovicPeix, Amalia (55899478200)Amalia (55899478200)PeixBertagna, Francesco (25632102900)Francesco (25632102900)BertagnaHang Bui, Dieu (56461286400)Dieu (56461286400)Hang BuiCunha, Carlos (35084837300)Carlos (35084837300)CunhaObaldo, Jerry (7801485022)Jerry (7801485022)ObaldoRodella, Carlo (31067520000)Carlo (31067520000)RodellaCamoni, Luca (54791955700)Luca (54791955700)CamoniPaez, Diana (54785022800)Diana (54785022800)PaezDondi, Maurizio (56789705600)Maurizio (56789705600)Dondi2025-06-122025-06-122014https://doi.org/10.1007/s12350-014-9983-4https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919786464&doi=10.1007%2fs12350-014-9983-4&partnerID=40&md5=868e38b013206669b38a97d6547bb737https://remedy.med.bg.ac.rs/handle/123456789/8475Background: Transient post-ischemic LV dysfunction due to myocardial stunning in patients with coronary artery disease can be missed by conventional gated SPECT (GSPECT) acquisitions. The aim of this IAEA-sponsored multi-center study was to determine whether early post-exercise imaging is more likely to detect stunning than conventional without adversely affecting image quality or perfusion information.; Methods and Results: Patients undergoing exercise/rest GSPECT were enrolled in this international multicenter study. Post-exercise studies were acquired at 15 ± 5 minutes after radiotracer injection (Stress-1) and repeated at 60 ± 15 minutes (Stress-2). Rest studies (R) were acquired at 60 minutes post injection. A core laboratory quantitatively assessed perfusion pattern and LV blinded to the acquisition time. Ischemia was defined as summed stress score (SDS) ≥4, and stunning was defined as the difference between rest and post-stress LVEF (Δ-LVEF). In the 229 patients enrolled into the study, both image quality and perfusion information were similar between Stress-1 and Stress-2. Post-stress LVEF was associated with both ischemia and time of acquisition, with a significant correlation between SDS and Δ-LVEF, which was stronger at Stress-1 than Stress-2 in the ischemic compared to the non-ischemic population (r = 0.23 vs 0.08, P = 0.10).; Conclusions: Early post-exercise imaging is feasible, and can potentially improve the detection of post-ischemic stunning without compromising image quality and perfusion data © 2014, American Society of Nuclear Cardiology.exercise: stress testinggated SPECTischemic myocardial dysfunctionLeft ventricular function