Ducic, Sinisa (22950480700)Sinisa (22950480700)DucicMilanovic, Filip (57220590207)Filip (57220590207)MilanovicLazovic, Mikan (57208187125)Mikan (57208187125)LazovicBukva, Bojan (55516005300)Bojan (55516005300)BukvaDjuricic, Goran (59157834100)Goran (59157834100)DjuricicRadlovic, Vladimir (25121643300)Vladimir (25121643300)RadlovicNikolic, Dejan (26023650800)Dejan (26023650800)Nikolic2025-06-122025-06-122022https://doi.org/10.3390/children9050762https://www.scopus.com/inward/record.uri?eid=2-s2.0-85131369494&doi=10.3390%2fchildren9050762&partnerID=40&md5=89eb766217003a94e7990741128a74f6https://remedy.med.bg.ac.rs/handle/123456789/3468Background: The forearm is the most common fracture site in childhood, accounting for every fourth pediatric fracture. It is well described that vitamin D is involved in the regulation of bone mineralization and skeletal homeostasis by the regulation of calcium absorption. The aim of our study was to determine the influence of 25-hydroxyvitamin D levels on forearm fracture falls in a pediatric population, depending on level of energy impact. Additionally, we also aimed to evaluate the correlation between 25-hydroxyvitamin D levels and other tested risk factors for pediatric fractures. Methods: We evaluated 50 eligible children aged 3 to 12 years with a forearm fracture. According to energy impact, patients were grouped into low-energy fractures (LEF) and high-energy fractures (HEF) groups. The general characteristics of the patients included age, gender, sport participation, and fractured bone and its localization. We analyzed 25-hydroxyvitamin D, parathyroid hormone (PTH), calcium, magnesium, phosphate, C-reactive protein (CRP) levels, and body mass index (BMI). Results: There is a significant difference in the 25-hydroxyvitamin D levels distribution between LEF and HEF (p < 0.001) and PTH levels (p = 0.002). For magnesium levels, calcium levels, phosphate levels, and CRP levels, there were no significant differences in their frequency distribution. For the group of patients with LEF, there is a significantly positive correlation between 25-hydroxyvitamin D and calcium levels (p = 0.019) and a borderline significantly positive correlation between 25hydroxyvitamin D and magnesium levels (p = 0.050). For the group of patients with HEF, there was only a significantly positive correlation between 25-hydroxyvitamin D and PTH levels (p < 0.001). Conclusions: Children with LEF were more frequently insufficient in 25-hydroxyvitamin D levels but had normal calcium levels, compared to the ones with HEF. These findings suggest that LEF and HEF in children might to a certain degree have different pathophysiological mechanisms. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.25-hydroxyvitamin Dbone metabolismchildrenforearmfractures