Kovač, Jelena Djokić (52563972900)Jelena Djokić (52563972900)KovačGalun, Danijel (23496063400)Danijel (23496063400)GalunĐurić-Stefanović, Aleksandra (16021199600)Aleksandra (16021199600)Đurić-StefanovićLilić, Gordana (8239856400)Gordana (8239856400)LilićVasin, Dragan (56946704000)Dragan (56946704000)VasinLazić, Ljubica (36093093100)Ljubica (36093093100)LazićMašulović, Dragan (57215645003)Dragan (57215645003)MašulovićŠaranović, Đorđije (57190117313)Đorđije (57190117313)Šaranović2025-07-022025-07-022017https://doi.org/10.1177/0284185117695666https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032926176&doi=10.1177%2f0284185117695666&partnerID=40&md5=d40b7545f7e87fb1dec05c9c719b44bchttps://remedy.med.bg.ac.rs/handle/123456789/13115Background: Intrahepatic mass-forming cholangiocellular carcinoma (IMC) is the second most common primary liver tumor. The differentiation between IMC and solitary hypovascular liver metastases (SHLM) represents a diagnostic challenge due to many overlapping magnetic resonance imaging (MRI) features. Purpose: To determine the value of diffusion-weighted imaging (DWI) in addition to conventional MRI for the distinction between intrahepatic mass-forming cholangiocarcinoma and solitary hypovascular liver metastases. Material and Methods: Fifty-three patients with pathologically proven IMC (n = 31) and SHLM (n = 22) who had undergone MRI and DWI before surgery or percutaneous biopsy were enrolled in this study. The following MRI features were analyzed: the size and shape of the lesion, presence of capsular retraction and segmental biliary dilatation, T2-weighted (T2W) signal intensity, the presence of target sign on DWI and enhancement pattern. Apparent diffusion coefficient (ADC) values were calculated for each lesion (b = 800 s/mm2). Univariate and multivariate logistic regression analyses were used to identify significant differentiating features between IMCs and SHLMs. Results: Univariate analysis revealed that following parameters favor diagnosis of IMCs over SHLMs: lobulating shape, heterogeneous T2W signal intensity, capsular retraction, segmental biliary dilatation, target sign on DWI and rim-like enhancement on arterial phase followed by progressive enhancement in delayed phases. ADC values measured in the periphery of the lesion were significantly lower in IMCs in comparison to SHLMs. Multivariate analysis revealed that target sign on DWI was the most significant predictor of IMCs. Conclusion: Qualitative DWI analysis with target sign significantly improves diagnostic accuracy for differentiation among IMC and SHLM lesions. © 2017, © The Foundation Acta Radiologica 2017.diffusion weighted imagingIntrahepatic mass-forming cholangiocarcinomamagnetic resonance imaging (MRI)solitary hypovascular liver lesions