Ilic, Milena (7102981394)Milena (7102981394)IlicKocic, Sanja (34880317700)Sanja (34880317700)KocicRadovanovic, Djordje (57205352924)Djordje (57205352924)RadovanovicMacuzic, Ivana Zivanovic (23570133700)Ivana Zivanovic (23570133700)MacuzicIlic, Irena (57210823522)Irena (57210823522)Ilic2025-06-122025-06-122019https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067657589&partnerID=40&md5=d8a282497a5e3937ee9873dfd85384bahttps://remedy.med.bg.ac.rs/handle/123456789/5617Purpose: Esophageal cancer mortality trends vary substantially across the world. This study assessed the trend of esophageal cancer mortality in Serbia. Methods: A population-based study analyzing esophageal cancer mortality in Serbia in the period 1991-2015 was carried out based on official data. The annual percentage of change (APC), with the 95% confidence interval (CI), was computed using the joinpoint regression analysis. The age, period and birth cohort effects on the mortality from esophageal cancer were examined using the age-period-cohort analysis. Results: In Serbia, esophageal cancer mortality trend significantly increased from 1991 to 2015 in men (APC=+0.9%, 95%CI=0.3 to 1.4), but nonsignificantly increased in women (APC=+0.4%, 95%CI=-0.6 to 1.4). The age-specific mortality rates were increasing with age, but this trend has only been significant in men in the 50-59 years age group (APC=+1.5%, 95%CI= 0.8 to 2.3). The age-period-cohort analysis suggested statistically non-significant period and cohort effects, and local drifts for both genders (p>0.05 for all). Conclusions: The trend of esophageal cancer mortality should be elucidated in future analytical epidemiological studies in Serbia. © 2019 Zerbinis Publications. All rights reserved.Age-period-cohort analysisEsophageal cancerJoinpoint analysisMortality trend