Ilic, Branislav (58121227500)Branislav (58121227500)IlicNikolic, Nadja (55324775800)Nadja (55324775800)NikolicAndric, Miroslav (20435687400)Miroslav (20435687400)AndricJelovac, Drago (58449716800)Drago (58449716800)JelovacMilicic, Biljana (6603829143)Biljana (6603829143)MilicicJozic, Tanja (6504760115)Tanja (6504760115)JozicKrstic, Slobodan (9238904400)Slobodan (9238904400)KrsticMilasin, Jelena (6603015594)Jelena (6603015594)Milasin2025-06-122025-06-122017https://doi.org/10.1111/jop.12564https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014576383&doi=10.1111%2fjop.12564&partnerID=40&md5=6c0699281be38d95395eb75432d524eehttps://remedy.med.bg.ac.rs/handle/123456789/7029Background: Polymorphisms in genes encoding tumor necrosis factor-α (TNF-α) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-α (−308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. Methods: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. Results: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P < 0.05). Carriers of the TNF-α A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98–16.56, P < 0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR=3.65, CI: 1.60–8.40, P = 0.001). Conclusions: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltdodontogenic tumorsrisk factorssingle nucleotide polymorphismsTNFR1tumor necrosis factor-α