Atherogenic impact of homocysteine: Can hmg-coa reductase inhibitors additionally influence hyperhomocysteinaemia?; [Aterogeni potencijal homocisteina: Da li inhibitori hmg-coa reduktaze mogu uticati i na hiperhomocisteinemiju?]

Nikolic, Tamara (56425849500)Tamara (56425849500)NikolicSrejovic, Ivan (55754581700)Ivan (55754581700)SrejovicStojic, Isidora (55696426400)Isidora (55696426400)StojicJeremic, Jovana (56728450400)Jovana (56728450400)JeremicFolic, Marko (35098654700)Marko (35098654700)FolicMatic, Stevan (57201446596)Stevan (57201446596)MaticRakocevic, Milena (57216575040)Milena (57216575040)RakocevicJancic, Snezana (18434143700)Snezana (18434143700)JancicJakovljevic, Biljana (57191337771)Biljana (57191337771)JakovljevicObrenovic, Radmila (56199010700)Radmila (56199010700)ObrenovicDjuric, Dusan (35589783700)Dusan (35589783700)DjuricZivkovic, Vladimir (55352337400)Vladimir (55352337400)Zivkovic2025-06-122025-06-122019https://doi.org/10.1515/SJECR-2017-0055https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054776069&doi=10.1515%2fSJECR-2017-0055&partnerID=40&md5=9309b2697e4981e8c88a2d969dd73721https://remedy.med.bg.ac.rs/handle/123456789/5987The strong association among the risk of coronary artery diseases (CAD), high levels of LDL-C and low levels of HDL-C is well established. Hyperhomocysteinaemia (HHcy) is an independent risk factor for cardiovascular disease (CVD) and causes endothelial dysfunction, a hallmark of atherosclerosis. In this study, we ascertained the influence of statins on the atherogenic index, as an indicator and a significant adjunct for predicting atherosclerosis in hyperhomocysteinaemic male Wistar albino rats. For 4 weeks, the animals were fed with one of the following diets (Mucedola SRL., Milan, Italy): standard rodent chow; a diet enriched in methionine with no deficiency in B vitamins or a diet enriched in methionine and deficient in B vitamins. The animals were simultaneously exposed to a pharmacology treatment with atorvastatin at dose of 3 mg/kg/day i.p. or simvastatin, at dose of 5 mg/kg/day i.p. We measured weight gain, food intake, and FER and determined the concentrations of biochemical parameters of dyslipidaemia (TC, TGs, LDL-C, VLDL-C, and HDL-C), AI, and CRR. A histopathological examination was conducted on portions of the right and left liver lobes from each animal. A connection between Hhcy and dyslipidaemia was indicated by the findings of biochemical and histological analyses, suggesting that Hhcy was a pro-atherogenic state. An improvement in the lipid profile along with a decrease in the atherogenic index by statins suggests that atorvastatin and simvastatin could be useful antiatherogenic agents, with protective activities during hyperhomocysteinaemia. © 2019, University of Kragujevac, Faculty of Science. All rights reserved.Atherogenic indexHmg-coa reductase inhibitorsHyperhomocysteinaemiaLiverAtherogenic impact of homocysteine: Can hmg-coa reductase inhibitors additionally influence hyperhomocysteinaemia?; [Aterogeni potencijal homocisteina: Da li inhibitori hmg-coa reduktaze mogu uticati i na hiperhomocisteinemiju?]