Skoric, Dejan (6602687814)Dejan (6602687814)SkoricIvana, Joksic (55908293200)Joksic (55908293200)IvanaTanja, Radic (55908247900)Radic (55908247900)TanjaJovana, Jakovljevic (55908583800)Jakovljevic (55908583800)JovanaPetar, Ivanovski (55908880500)Ivanovski (55908880500)PetarTatjana, Simic (55909059900)Simic (55909059900)Tatjana2025-06-122025-06-122014https://doi.org/10.1097/MPH.0000000000000050https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897474017&doi=10.1097%2fMPH.0000000000000050&partnerID=40&md5=897e0e60abdafe0d469708372aef061fhttps://remedy.med.bg.ac.rs/handle/123456789/8885BACKGROUND: Therapy-induced leukemia is a well-known clinical syndrome occurring as a late complication in patients treated with cytotoxic therapy. OBSERVATION: We herein present results of analysis of common gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) genes in a 10-year-old boy who developed very rare type of cancer, mixed phenotype acute leukemia, 6 years after treatment of acute lymphoblastic leukemia. CONCLUSIONS: Impairment in function of GST and MTHFR enzymes found in our patient may have contributed to the development of secondary mixed phenotype acute leukemia, although precise mechanism remains elusive. © 2014 by Lippincott Williams & Wilkins.gene polymorphismglutathione S-transferasemethylenetetrahydrofolate reductaseMixed phenotype acute leukemia