Peric, Stojan (35750481700)Stojan (35750481700)PericBozovic, Ivo (57194468421)Ivo (57194468421)BozovicNisic, Tanja (21734578900)Tanja (21734578900)NisicBanovic, Marija (57190309026)Marija (57190309026)BanovicVujnic, Milorad (56079611800)Milorad (56079611800)VujnicSvabic, Tamara (54783513300)Tamara (54783513300)SvabicPesovic, Jovan (15725996300)Jovan (15725996300)PesovicBrankovic, Marija (58122593400)Marija (58122593400)BrankovicBasta, Ivana (8274374200)Ivana (8274374200)BastaJankovic, Milena (54881096000)Milena (54881096000)JankovicSavic-Pavicevic, Dusanka (18435454500)Dusanka (18435454500)Savic-PavicevicRakocevic-Stojanovic, Vidosava (6603893359)Vidosava (6603893359)Rakocevic-Stojanovic2025-06-122025-06-122019https://doi.org/10.1007/s10072-019-03763-0https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064817044&doi=10.1007%2fs10072-019-03763-0&partnerID=40&md5=f28b7359f28ecda50709d1aca1668327https://remedy.med.bg.ac.rs/handle/123456789/5570Introduction: To date, there are only several reports on body composition in myotonic dystrophy type 1 (DM1) and there are no data for myotonic dystrophy type 2 (DM2). The aim was to analyze body composition of patients with DM1 and DM2, and its association with socio-demographic and clinical features of the diseases. Methods: There were no statistical differences in sociodemographic features between 20 DM1 patients and 12 DM2 patients. Body composition was assessed by DEXA (dual-energy x-ray absorptiometry). A three-compartment model was used: bone mineral content (BMC), fat mass (FM), and lean tissue mass (LTM). Results: Patients with DM1 and DM2 had similar total body mass (TBM), BMC, FM, and LTM. Patients with DM1 had higher trunk-limb fat index (TLFI) in comparison to DM2 patients which indicates visceral fat deposition in DM1 (1.16 ± 0.32 for DM1 vs. 0.87 ± 0.23 for DM2, p < 0.05). Right ribs bone mineral density was lower in DM2 group (0.68 ± 0.07 g/cm 2 vs. 0.61 ± 0.09 g/cm 2 , p < 0.05). Higher percentage of FM in legs showed correlation with lower strength of the upper leg muscles in DM1 (ρ = − 0.47, p < 0.05). Higher muscle strength in DM2 patients was in correlation with higher bone mineral density (ρ = + 0.62, p < 0.05 for upper arm muscles, ρ = + 0.87, p < 0.01 for lower arm muscles, ρ = + 0.72, p < 0.05 for lower leg muscles). Conclusion: DM1 patients had visceral obesity, and percentage of FM correlated with a degree of muscle weakness in upper legs. In DM2 patients, degree of muscle weakness was in correlation with higher FM index and lower bone mineral density. © 2019, Fondazione Società Italiana di Neurologia.Body compositionBone mineral densityMuscle weaknessMyotonic dystrophy type 1Myotonic dystrophy type 2Visceral obesity