Panic, Nikola (54385649700)Nikola (54385649700)PanicMihajlovic, Sladjana (57191859364)Sladjana (57191859364)MihajlovicVujasinovic, Miroslav (54979883900)Miroslav (54979883900)VujasinovicBulajic, Milutin (7003421663)Milutin (7003421663)BulajicLöhr, Johannes-Matthias (55665962800)Johannes-Matthias (55665962800)Löhr2025-06-122025-06-122020https://doi.org/10.3390/jcm9103309https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105429538&doi=10.3390%2fjcm9103309&partnerID=40&md5=21d526840863a5c5356443c55f2eaf5dhttps://remedy.med.bg.ac.rs/handle/123456789/4699Background: We conducted a systematic review in order to summarize the available data on pancreatitis associated with viral hepatitis. Methods: A comprehensive literature search of Medline, Scopus and ISI Web of Science databases was conducted and papers eligible for the inclusion identified. Results: In total, 46 studies reporting data on 73 patients were included in the analysis. Most of the cases were diagnosed in Asia (57.53%), followed by North America (23.29%), and Europe (13.70%). Most of the patients were affected by hepatitis A virus (HAV) (42.47%), followed by hepatitis E virus (HEV) (28.77%), hepatitis B virus (HBV) (8.22%), and hepatitis C virus (HCV) (1.37%), while 17.81% at the time of diagnosis were classified as affected by “hepatitis virus”. Pancreatitis was severe in 32.88% of cases. The respiratory system was affected in 2.74% of patients, 6.85% experienced renal failure, while 5.48% experienced a multiorgan dysfunction syndrome (MODS). Four patients (5.48%) needed pancreatic surgery. Despite the treatment, 21.92% of patients died. We identified fulminant hepatitis (p < 0.0001), MODS (p < 0.0001) and severe pancreatitis (p < 0.0001) to be significantly more present in patients who died in comparison to cured ones. Conclusion: Increased awareness of pancreatic involvement in viral hepatitis is needed because it can have a substantial impact on therapeutic approaches and outcomes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.HepatitisPancreatitisViral