Siméon, Soline (56091330000)Soline (56091330000)SiméonMassy, Ziad (7005894966)Ziad (7005894966)MassyHøjlund, Kurt (6603935402)Kurt (6603935402)HøjlundLalic, Katarina (13702563300)Katarina (13702563300)LalicPorcellati, Francesca (6602763864)Francesca (6602763864)PorcellatiDekker, Jacqueline (7202456967)Jacqueline (7202456967)DekkerPetrie, John (7103382892)John (7103382892)PetrieCurrie, Gemma (56816475300)Gemma (56816475300)CurrieBalkau, Beverley (7005943124)Beverley (7005943124)Balkau2025-06-122025-06-122018https://doi.org/10.1186/s12882-018-0918-1https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047903561&doi=10.1186%2fs12882-018-0918-1&partnerID=40&md5=f5c4af1d36d91cb9250ed54eacb4e596https://remedy.med.bg.ac.rs/handle/123456789/6296Background: People with chronic renal disease are insulin resistant. We hypothesized that in a healthy population, baseline renal function is associated with insulin sensitivity three years later. Methods: We studied 405 men and 528 women from the European Group for the study of Insulin Resistance - Relationship between Insulin Sensitivity and Cardiovascular disease cohort. Renal function was characterized by the estimated glomerular filtration rate (eGFR) and by the urinary albumin-creatinine ratio (UACR). At baseline only, insulin sensitivity was quantified using a hyperinsulinaemic-euglycaemic clamp; at baseline and three years, we used surrogate measures: the Matsuda insulin sensitivity index (ISI), the HOmeostasis Model Assessment of Insulin Sensitivity (HOMA-IS). Associations between renal function and insulin sensitivity were studied cross-sectionally and longitudinally. Results: In men at baseline, no associations were seen with eGFR, but there was some evidence of a positive association with UACR. In women, all insulin sensitivity indices showed the same negative trend across eGFR classes, albeit not always statistically significant; for UACR, women with values above the limit of detection, had higher clamp measured insulin sensitivity than other women. After three years, in men only, ISI and HOMA-IS showed a U-shaped relation with baseline eGFR; women with eGFR> 105 ml/min/1.73m2 had a significantly higher insulin sensitivity than the reference group (eGFR: 90-105 ml/min/1.73m2). For both men and women, year-3 insulin sensitivity was higher in those with higher baseline UACR. All associations were attenuated after adjusting on significant covariates. Conclusions: There was no evidence to support our hypothesis that markers of poorer renal function are associated with declining insulin sensitivity in our healthy population. © 2018 The Author(s).AlbuminuriaCohortEpidemiologyGlomerular filtration rateInsulin sensitivityRenal functionSex