Dragasevic, Sanja (56505490700)Sanja (56505490700)DragasevicStankovic, Biljana (35785023700)Biljana (35785023700)StankovicKotur, Nikola (54961068500)Nikola (54961068500)KoturSokic-Milutinovic, Aleksandra (55956752600)Aleksandra (55956752600)Sokic-MilutinovicMilovanovic, Tamara (55695651200)Tamara (55695651200)MilovanovicLukic, Snezana (25028136800)Snezana (25028136800)LukicMilosavljevic, Tomica (7003788952)Tomica (7003788952)MilosavljevicSrzentic Drazilov, Sanja (57204289670)Sanja (57204289670)Srzentic DrazilovKlaassen, Kristel (54959837700)Kristel (54959837700)KlaassenPavlovic, Sonja (7006514877)Sonja (7006514877)PavlovicPopovic, Dragan (7201969148)Dragan (7201969148)Popovic2025-06-122025-06-122020https://doi.org/10.1089/met.2019.0090https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078868612&doi=10.1089%2fmet.2019.0090&partnerID=40&md5=d350dd2a71ca52b3d8025aee52e74650https://remedy.med.bg.ac.rs/handle/123456789/5041Background: This study analyzed poorly understood relationship of two overlapping conditions: metabolic syndrome (MeS) and inflammatory bowel disease (IBD), both associated with inflammation in the visceral adipose tissue. Methods: Newly diagnosed 104 IBD patients, of which 50 Crohn's disease (CD) and 54 ulcerative colitis (UC), and 45 non-IBD controls were examined for MeS-related obesity and lipid markers. Th-17 immune genes IL17A, IL17F, IL23A, and TLR9 mRNAs were measured in intestinal mucosa by qRT-PCR. Subjects were genotyped for obesity-associated FTO variant rs9939609 by polymerase chain reaction-amplification refractory mutation system. Results: CD was associated with MeS (P = 0.01), while both CD and UC were associated with central obesity (P = 10-5, P = 0.002, respectively) and low levels of high-density lipoprotein (HDL) cholesterol (P = 5 × 10-6, P = 6 × 10-6, respectively). IBD lipid profile was characterized by decreased total and HDL cholesterol, while low-density lipoprotein cholesterol was reduced only in CD. Negative correlations were found between total cholesterol and CD activity index (P = 0.005), waist circumference and IL17A as well as IL17F mRNA levels in inflamed CD colon (P = 0.003, P = 0.001, respectively). Carriers of FTO rs9939609 AA genotype showed increased risk of CD (OR 2.6, P = 0.01). Conclusions: MeS, central obesity, and dyslipidemia could be important for IBD pathogenesis. This could influence therapeutic approaches and prevention strategies in high-risk groups. © Copyright 2020, Mary Ann Liebert, Inc., publishers 2020.central obesitydyslipidemiaFTOIBDTh-17 genes expression