Stefanovic, P. (57196880217)P. (57196880217)StefanovicBasta-Javanovich, G. (6504798969)G. (6504798969)Basta-JavanovichRadak, D. (7004442548)D. (7004442548)RadakRosato, E. (35918111400)E. (35918111400)RosatoCannistra, C. (6701746865)C. (6701746865)CannistraBenhamou, G. (7005717858)G. (7005717858)Benhamou2025-06-122025-06-121997https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030801484&partnerID=40&md5=a4b4964ae549ae3369c3ab04c30c286chttps://remedy.med.bg.ac.rs/handle/123456789/1581Histicytosis X is the generic term for a group of three diseases having similar clinical features: eosinophilic granuloma, Hand-Schuller-Christian disease and Letterer-Sive disease. These diseases occurr mostly in children and young adults and progress rapidly with fatal spreading from a solitary skin or soft tissue lesion. Primary lesions affecting the head and neck usually carry the most severe prognosis. We present the case of a 54 yrs old patient who presented with histicytosis X in the form of a solitary mandibular lesion. The patient initially underwent surgical treatment by curettage, as indicated by protocols, but presented with local recurrence a year later. Ample resection of the mandible was then undertaken and reconstruction was achieved by an iliac autograft. Clinical and radiological check-ups show no evidence of local or systemic recurrence after a period of three years.