Ogrizovic, Sanja Simic (55923197400)Sanja Simic (55923197400)OgrizovicBojic, Suzana (55965837500)Suzana (55965837500)BojicBasta-Jovanovic, Gordana (6603093303)Gordana (6603093303)Basta-JovanovicRadojevic, Sanja (56581990900)Sanja (56581990900)RadojevicPavlovic, Jelena (57198008443)Jelena (57198008443)PavlovicStevuljevic, Jelena Kotur (36629424300)Jelena Kotur (36629424300)StevuljevicDopsaj, Violeta (6507795892)Violeta (6507795892)DopsajNaumovic, Radomir (55965061800)Radomir (55965061800)Naumovic2025-06-122025-06-122013https://doi.org/10.1155/2013/183246https://www.scopus.com/inward/record.uri?eid=2-s2.0-84890422684&doi=10.1155%2f2013%2f183246&partnerID=40&md5=f9e7919f00ef6aa9d31842f582bc6878https://remedy.med.bg.ac.rs/handle/123456789/9329Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later. Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = ?0.572), GFR6 (r = ?0.442), GFR24 (r = ?0.398), and GFR36 (r = ?0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (P = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest. Copyright © 2013 Peter Kruzliak et al.