Pekic, Sandra (6602553641)Sandra (6602553641)PekicSoldatovic, Ivan (35389846900)Ivan (35389846900)SoldatovicMiljic, Dragana (6505968542)Dragana (6505968542)MiljicStojanovic, Marko (58191563300)Marko (58191563300)StojanovicDoknic, Mirjana (6603478362)Mirjana (6603478362)DoknicPetakov, Milan (7003976693)Milan (7003976693)PetakovPopovic, Vera (57294508600)Vera (57294508600)Popovic2025-06-122025-06-122019https://doi.org/10.1007/s12672-018-0348-3https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053063841&doi=10.1007%2fs12672-018-0348-3&partnerID=40&md5=70e7602872a99aac5a0394f9b5409991https://remedy.med.bg.ac.rs/handle/123456789/5732People are at higher risk for malignancy as they get older or have a strong family history of cancer. This study aims to collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in outpatient clinic from years 2005–2017. Overall, 46.6% of 1062 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas which was significantly higher than in families of patients with non-functioning pituitary adenomas (NFPA) (10.0%) or acromegaly (6.8%) (p = 0.004). Lung cancer in family members was reported in 12.1% of patients with prolactinomas, significantly higher than in families of NFPA patients (7.0%, p = 0.049). Colorectal cancer in relatives of patients with PA was reported with any type of PA. Furthermore, patients with a positive family history of malignancy were diagnosed with PA at an earlier age than patients with a negative family history (43.6 ± 15.9 vs 46.0 ± 16.4 years, p = 0.015). Female patients with prolactinoma are more commonly diagnosed before the age of 25 years. Forty-two percent of patients with PA diagnosed before the age of 25 years had a second- and third-degree relative with cancer, significantly higher than patients with PA diagnosed later in life (25.8%, p < 0.001). Breast, lung, and colon cancers in second- and third-degree relatives were reported in significantly higher proportion of patients with PA diagnosed before the age of 25 years, compared with patients with PA diagnosed later in life (breast cancer: 10.9 vs 6.1%, p = 0.033; lung cancer: 10.9 vs 5.8%, p = 0.02; colon cancer: 9.5 vs 4.0%, p = 0.004). These results suggest familial cancer clustering in patients with prolactinoma and young patients with PA (younger than 25 years at diagnosis of PA). In particular, there is a strong association between prolactinoma and family history of breast and lung cancers. Further research of possible shared genetic susceptibility of prolactinoma and breast and lung cancers is needed. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.Breast cancerCancerFamily historyPituitary adenomaProlactinoma