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(36044041500)OwenHolmans, Peter (57172024600)Peter (57172024600)HolmansWilliams, Nigel (57222346583)Nigel (57222346583)WilliamsCraddock, Nicholas (35352014300)Nicholas (35352014300)CraddockRichards, Alexander (57214750824)Alexander (57214750824)RichardsHumphreys, Isla (57192951008)Isla (57192951008)HumphreysMeyer-Lindenberg, Andreas (35272702000)Andreas (35272702000)Meyer-LindenbergLeweke, F. Markus (7003477591)F. Markus (7003477591)LewekeTost, Heike (7003746529)Heike (7003746529)TostAkdeniz, Ceren (56066476900)Ceren (56066476900)AkdenizRohleder, Cathrin (55928440200)Cathrin (55928440200)RohlederBumb, J. Malte (55504136600)J. Malte (55504136600)BumbSchwarz, Emanuel (57197073681)Emanuel (57197073681)SchwarzAlptekin, Köksal (6601988494)Köksal (6601988494)AlptekinÜçok, Alp (57200577911)Alp (57200577911)ÜçokSaka, Meram Can (57226208817)Meram Can (57226208817)SakaAtbagoǧlu, E. Cem (57226207974)E. Cem (57226207974)AtbagoǧluGülöksüz, Sinan (57215571180)Sinan (57215571180)GülöksüzGumus-Akay, Guvem (57215615007)Guvem (57215615007)Gumus-AkayCihan, Burçin (56208776100)Burçin (56208776100)CihanKaradaǧ, Hasan (27967771500)Hasan (27967771500)KaradaǧSoygür, Haldan (6507427562)Haldan (6507427562)SoygürCankurtaran, Eylem Şahin (55888901400)Eylem Şahin (55888901400)CankurtaranUlusoy, Semra (6603926074)Semra (6603926074)UlusoyAkdede, Berna (7801341519)Berna (7801341519)AkdedeBinbay, Tolga (26424249900)Tolga (26424249900)BinbayAyer, Ahmet (24366260000)Ahmet (24366260000)AyerNoyan, Handan (56209007800)Handan (56209007800)NoyanKaradayi, Gülgah (26666092900)Gülgah (26666092900)KaradayiAkturan, Elçin (55565414500)Elçin (55565414500)AkturanUlaş, Halis (21744129800)Halis (21744129800)UlaşArango, Celso (6508338058)Celso (6508338058)ArangoParellada, Mara (14040702000)Mara (14040702000)ParelladaBernardo, Miguel (7103259062)Miguel (7103259062)BernardoSanjuán, Julio (56416073600)Julio (56416073600)SanjuánBobes, Julio (7005688230)Julio (7005688230)BobesArrojo, Manuel (55910807500)Manuel (55910807500)ArrojoSantos, Jose Luis (56599622200)Jose Luis (56599622200)SantosCuadrado, Pedro (57188948339)Pedro (57188948339)CuadradoSolano, José Juan Rodríguez (56208605200)José Juan Rodríguez (56208605200)SolanoCarracedo, Angel (7006062179)Angel (7006062179)CarracedoBernardo, Enrique García (56208645400)Enrique García (56208645400)BernardoRoldán, Laura (56208718600)Laura (56208718600)RoldánLópez, Gonzalo (56208654200)Gonzalo (56208654200)LópezCabrera, Bibiana (9241557000)Bibiana (9241557000)CabreraCruz, Sabrina (56208594700)Sabrina (56208594700)CruzMesa, Eva M. Díaz (35338935200)Eva M. Díaz (35338935200)MesaPouso, María (57207275124)María (57207275124)PousoJiménez, Estela (57226234799)Estela (57226234799)JiménezSánchez, Teresa (56168383900)Teresa (56168383900)SánchezRapado, Marta (24512520700)Marta (24512520700)RapadoGonzález, Emiliano (57199756348)Emiliano (57199756348)GonzálezMartínez, Covadonga (56208998400)Covadonga (56208998400)MartínezSánchez, Emilio (56209073500)Emilio (56209073500)SánchezOlmeda, M. Soledad (56208658300)M. Soledad (56208658300)OlmedaDe Haan, Lieuwe (7005592387)Lieuwe (7005592387)De HaanVelthorst, Eva (57193569808)Eva (57193569808)VelthorstVan Der Gaag, Mark (57211064266)Mark (57211064266)Van Der GaagSelten, Jean-Paul (7004379701)Jean-Paul (7004379701)SeltenVan Dam, Daniella (55447940700)Daniella (55447940700)Van DamVan Der Ven, Elsje (44861788000)Elsje (44861788000)Van Der VenVan Der Meer, Floor (54780753400)Floor (54780753400)Van Der MeerMesschaert, Elles (56209133900)Elles (56209133900)MesschaertKraan, Tamar (56208698700)Tamar (56208698700)KraanBurger, Nadine (56208538800)Nadine (56208538800)BurgerLeboyer, Marion (7005287140)Marion (7005287140)LeboyerSzoke, Andrei (7007174299)Andrei (7007174299)SzokeSchürhoff, Franck (57207726175)Franck (57207726175)SchürhoffLlorca, Pierre-Michel (7003468273)Pierre-Michel (7003468273)LlorcaJamain, Stéphane (6602181887)Stéphane (6602181887)JamainTortelli, Andrea (6507197913)Andrea (6507197913)TortelliFrijda, Flora (56208843100)Flora (56208843100)FrijdaVilain, Jeanne (35093392000)Jeanne (35093392000)VilainGalliot, Anne-Marie (54389067500)Anne-Marie (54389067500)GalliotBaudin, Grégoire (56173270200)Grégoire (56173270200)BaudinFerchiou, Aziz (57203832931)Aziz (57203832931)FerchiouRichard, Jean-Romain (57204623943)Jean-Romain (57204623943)RichardBulzacka, Ewa (36547252900)Ewa (36547252900)BulzackaCharpeaud, Thomas (47561183400)Thomas (47561183400)CharpeaudTronche, Anne-Marie (22982044400)Anne-Marie (22982044400)TroncheDe Hert, Marc (7004425915)Marc (7004425915)De HertVan Winkel, Ruud (57211720800)Ruud (57211720800)Van WinkelDecoster, Jeroen (25648836100)Jeroen (25648836100)DecosterDerom, Catherine (7003348389)Catherine (7003348389)DeromThiery, Evert (7004055701)Evert (7004055701)ThieryStefanis, Nikos C. (35584962800)Nikos C. (35584962800)StefanisSachs, Gabriele (7202202756)Gabriele (7202202756)SachsAschauer, Harald (57203881380)Harald (57203881380)AschauerLasser, Iris (55136246300)Iris (55136246300)LasserWinklbaur, Bernadette (13104714800)Bernadette (13104714800)WinklbaurSchlögelhofer, Monika (57189313037)Monika (57189313037)SchlögelhoferRiecher-Rössler, Anita (57226214736)Anita (57226214736)Riecher-RösslerBorgwardt, Stefan (12240845100)Stefan (12240845100)BorgwardtWalter, Anna (55444365800)Anna (55444365800)WalterHarrisberger, Fabienne (56097031800)Fabienne (56097031800)HarrisbergerSmieskova, Renata (26635908500)Renata (26635908500)SmieskovaRapp, Charlotte (55449460400)Charlotte (55449460400)RappIttig, Sarah (56208941300)Sarah (56208941300)IttigSoguel-Dit-Piquard, Fabienne (56209007500)Fabienne (56209007500)Soguel-Dit-PiquardStuderus, Erich (25926685100)Erich (25926685100)StuderusKlosterkötter, Joachim (7005883787)Joachim (7005883787)KlosterkötterRuhrmann, Stephan (6701546897)Stephan (6701546897)RuhrmannParuch, Julia (55879037000)Julia (55879037000)ParuchJulkowski, Dominika (55342611700)Dominika (55342611700)JulkowskiHilboll, Desiree (54947346200)Desiree (54947346200)HilbollSham, Pak C. (34573429300)Pak C. (34573429300)ShamCherny, Stacey S. (7004670001)Stacey S. (7004670001)ChernyChen, Eric Y.H. (57200371582)Eric Y.H. (57200371582)ChenCampbell, Desmond D. (57202328238)Desmond D. (57202328238)CampbellLi, Miaoxin (57192440066)Miaoxin (57192440066)LiRomeo-Casabona, Carlos María (57210606178)Carlos María (57210606178)Romeo-CasabonaCirión, Aitziber Emaldi (56129076500)Aitziber Emaldi (56129076500)CiriónMora, Asier Urruela (57191580809)Asier Urruela (57191580809)MoraJones, Peter (57212581099)Peter (57212581099)JonesKirkbride, James (57218240440)James (57218240440)KirkbrideCannon, Mary (7202419754)Mary (7202419754)CannonRujescu, Dan (57223450665)Dan (57223450665)RujescuTarricone, Ilaria (12762952600)Ilaria (12762952600)TarriconeBerardi, Domenico (57208023356)Domenico (57208023356)BerardiBonora, Elena (8581436000)Elena (8581436000)BonoraSeri, Marco (7005984572)Marco (7005984572)SeriMarcacci, Thomas (55097059100)Thomas (55097059100)MarcacciChiri, Luigi (20336507000)Luigi (20336507000)ChiriChierzi, Federico (54398124200)Federico (54398124200)ChierziStorbini, Viviana (56019351800)Viviana (56019351800)StorbiniBraca, Mauro (26533811200)Mauro (26533811200)BracaMinenna, Maria Gabriella (56018594100)Maria Gabriella (56018594100)MinennaDonegani, Ivonne (55207271100)Ivonne (55207271100)DoneganiFioritti, Angelo (57207084550)Angelo (57207084550)FiorittiLa Barbera, Daniele (57205552197)Daniele (57205552197)La BarberaLa Cascia, Caterina Erika (6601925392)Caterina Erika (6601925392)La CasciaMulè, Alice (35218035000)Alice (35218035000)MulèSideli, Lucia (35218187300)Lucia (35218187300)SideliSartorio, Rachele (57215751426)Rachele (57215751426)SartorioFerraro, Laura (57197842255)Laura (57197842255)FerraroTripoli, Giada (57197844215)Giada (57197844215)TripoliSeminerio, Fabio (56209250200)Fabio (56209250200)SeminerioMarinaro, Anna Maria (6603143974)Anna Maria (6603143974)MarinaroMcGorry, Patrick (35426378300)Patrick (35426378300)McGorryNelson, Barnaby (14071680700)Barnaby (14071680700)NelsonAmminger, G. Paul (6602664420)G. Paul (6602664420)AmmingerPantelis, Christos (7005521189)Christos (7005521189)PantelisMenezes, Paulo R. (7005549815)Paulo R. (7005549815)MenezesDel-Ben, Cristina M. (57204744667)Cristina M. (57204744667)Del-BenTenan, Silvia H. Gallo (56209215700)Silvia H. Gallo (56209215700)TenanShuhama, Rosana (57204887301)Rosana (57204887301)ShuhamaRuggeri, Mirella (7005660435)Mirella (7005660435)RuggeriTosato, Sarah (8672074400)Sarah (8672074400)TosatoLasalvia, Antonio (57197687797)Antonio (57197687797)LasalviaBonetto, Chiara (57195088072)Chiara (57195088072)BonettoIra, Elisa (55906699500)Elisa (55906699500)IraNordentoft, Merete (7006191523)Merete (7006191523)NordentoftKrebs, Marie-Odile (55342465700)Marie-Odile (55342465700)KrebsBarrantes-Vidal, Neus (6507516897)Neus (6507516897)Barrantes-VidalCristóbal, Paula (57215750983)Paula (57215750983)CristóbalKwapil, Thomas R. (6603921291)Thomas R. (6603921291)KwapilBrietzke, Elisa (57193167331)Elisa (57193167331)BrietzkeBressan, Rodrigo A. (7005575041)Rodrigo A. (7005575041)BressanGadelha, Ary (26667638000)Ary (26667638000)GadelhaMaric, Nadja P. (57226219191)Nadja P. (57226219191)MaricAndric, Sanja (57196427153)Sanja (57196427153)AndricMihaljevic, Marina (55345716000)Marina (55345716000)MihaljevicMirjanic, Tijana (16064153700)Tijana (16064153700)Mirjanic2025-06-122025-06-122014https://doi.org/10.1093/schbul/sbu069https://www.scopus.com/inward/record.uri?eid=2-s2.0-84902577447&doi=10.1093%2fschbul%2fsbu069&partnerID=40&md5=7ec99cfc9112ad7357b73ee828f2cf8ehttps://remedy.med.bg.ac.rs/handle/123456789/8830Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. © 2014 The Author.epidemiologygene-environment interactiongeneticspsychosisschizophrenia