Šutulović, Nikola (57015614000)Nikola (57015614000)ŠutulovićGrubač, Željko (57015105000)Željko (57015105000)GrubačŠuvakov, Sonja (36572404500)Sonja (36572404500)ŠuvakovJovanović, Đurđa (57209718540)Đurđa (57209718540)JovanovićPuškaš, Nela (15056782600)Nela (15056782600)PuškašMacut, Đuro (35557111400)Đuro (35557111400)MacutMarković, Aleksandra Rašić (23480382100)Aleksandra Rašić (23480382100)MarkovićSimić, Tatjana (6602094386)Tatjana (6602094386)SimićStanojlović, Olivera (6602159151)Olivera (6602159151)StanojlovićHrnčić, Dragan (13907639700)Dragan (13907639700)Hrnčić2025-06-122025-06-122019https://doi.org/10.1016/j.eplepsyres.2019.03.014https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063369464&doi=10.1016%2fj.eplepsyres.2019.03.014&partnerID=40&md5=d096627ececbf6d620f55d71f2a47eb4https://remedy.med.bg.ac.rs/handle/123456789/5527Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a result of interplay between psychological, immune, neurological and genetic factors, manifested by variety of urological, as well as brain-related symptoms. However, its relation with brain excitability has not been addressed. herefore, our aim was to assess susceptibility to seizures in rats with CP/CPPS. We induced CP/CPPS in adult rats by intraprostatic injection of 3% λ-carrageenan. Sham operated rats served as controls (0.9% NaCl, Sham). On day 7 upon injection, rats were treated with lindane (4 mg/kg) and observed for convulsive behavior (seizure incidence, latency and severity) and EEG manifestations (number and duration of ictal periods). Interleukin levels (IL-1β and IL-6) were measured in prostate, hippocampus, thalamus and cerebral cortex. Scrotal skin mechanical pain thresholds were determined and prostates were histologically evaluated. Animals with CP/CPPS showed significantly higher incidence, decreased latency time and augmented severity of lindane-induced seizures compared with Sham group. EEG revealed increased number of ictal periods in CP/CPPS rats. Higher levels of IL-1β and IL-6 were determined in the thalamus and cortex in CP/CPPS animals vs. Sham. IL-1β level was higher and IL-6 was lower in prostates from CP/CPPS animals comparing to Sham. CP/CPPS development was verified by histological findings of nonbacterial inflammation in the prostates, as well as by significantly decreased scrotal pain threshold in CP/CPPS animals. On the basis of this research, we concluded that CP/CPPS increases susceptibility to lindane-induced seizures in rats associated with increased level of IL-1β and IL-6 in the cortex and thalamus. © 2019 Elsevier B.V.Chronic Pelvic Pain SyndromeConvulsive SeizuresInterleukin 1betaInterleukin 6Wistar Rats