Milenkovic-Petronic, Dragica (24923372100)Dragica (24923372100)Milenkovic-PetronicMilojevic, Bogomir (36990126400)Bogomir (36990126400)MilojevicDjokic, Milan (15019194000)Milan (15019194000)DjokicSipetic-Grujicic, Sandra (6701802171)Sandra (6701802171)Sipetic-GrujicicMilojevic, Isidora Grozdic (37107616900)Isidora Grozdic (37107616900)MilojevicBumbasirevic, Uros (36990205400)Uros (36990205400)BumbasirevicDzamic, Zoran (6506981365)Zoran (6506981365)Dzamic2025-06-122025-06-122014https://doi.org/10.1007/s11255-013-0533-9https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896952063&doi=10.1007%2fs11255-013-0533-9&partnerID=40&md5=d209ba146f18c622ea7fea5f275db762https://remedy.med.bg.ac.rs/handle/123456789/8902Purpose: To investigate the association between tumor size and clinicopathologic factors and outcomes of upper urinary tract urothelial carcinoma (UTUC) in patients treated surgically for UTUC. Methods: A single-center series of 235 consecutive patients who were treated surgically for UTUC between January 1999 and December 2011 was evaluated. Patients with a history of muscle-invasive urothelial carcinoma of the urinary bladder, those who received neoadjuvant therapies, and those with previous contralateral UTUC were excluded. Bladder-only recurrence, any recurrence, and cancer-specific mortality after surgery were analyzed. Recurrence-free probabilities and cancer-specific survival (CSS) were estimated using the Kaplan-Meier method and Cox regression analyses. Results: Tumor size was significantly associated with age of the patient (P = 0.001), tumor location (P < 0.0001), tumor multifocality (P = 0.005), higher tumor stage (P < 0.0001), higher tumor grade (P = 0.038), lymphovascular invasion (P = 0.002), and mode of operation (P = 0.001). Tumor size was not associated with bladder-only recurrence (HR 0.91; 95 % CI 0.46-1.80; P = 0.79). The Kaplan-Meier method showed that tumor size >3 cm was significantly associated with worse CSS (P = 0.006, log rank). The 5-year CSS for patients with tumor size ≤3 cm was 70.1 % and for patients with tumor size >3 cm was 56.1 %. Tumor size was not associated with cancer-specific survival in multivariable analysis (HR 1.53; 95 % CI 0.89-2.61; P = 0.12). Conclusions: Tumor size >3 cm was associated with a lower 5-year CSS at Kaplan-Meier analysis, but was not an independent predictor of CSS, bladder-only recurrence, and any recurrence-free survival at multivariable analysis. © 2013 Springer Science+Business Media.RecurrenceSurvivalTumor sizeUpper urinary tract urothelial carcinoma