Paripović, Dušan (14621764400)Dušan (14621764400)ParipovićKostić, Mirjana (56247970900)Mirjana (56247970900)KostićKruščić, Divna (6602529198)Divna (6602529198)KruščićSpasojević, Brankica (10839232100)Brankica (10839232100)SpasojevićLomić, Gordana (55511852900)Gordana (55511852900)LomićMarković-Lipkovski, Jasmina (6603725388)Jasmina (6603725388)Marković-LipkovskiBasta-Jovanović, Gordana (6603093303)Gordana (6603093303)Basta-JovanovićSmoljanić, Željko (6602098756)Željko (6602098756)SmoljanićPeco-Antić, Amira (7004525216)Amira (7004525216)Peco-Antić2025-06-122025-06-122012https://doi.org/10.5301/jn.5000095https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862150583&doi=10.5301%2fjn.5000095&partnerID=40&md5=ff58b3dc49300915cc9c121c4e91dcf3https://remedy.med.bg.ac.rs/handle/123456789/9503Background: This study was conducted to retrospectively investigate the indications for renal biopsy in native kidneys and to analyze pathological findings in the last 10 years in a single tertiary pediatric hospital in Serbia. Methods: All patients who underwent renal biopsy at our hospital between 2001 and 2010 were included in the present study. Renal biopsy was performed under fluoroscopy with a biopsy gun. All renal biopsies were studied under light and immunofluorescent microscopy, while electron microscopy was rarely performed. Results: The study group included 150 patients (56% female) who underwent 158 percutaneous native kidney biopsies. Median age was 11.5 years (range 0.2-20 years). The most frequent indications for renal biopsy were nephrotic syndrome (32.9%), asymptomatic hematuria (23.4%), urinary abnormalities in systemic diseases (15.8%) and proteinuria (11.4%). Primary glomerulonephritis (GN) was the most common finding (57.4%), followed by secondary GN (15.5%) and tubulointerstitial diseases (4.5%). According to histopathological diagnosis, the most common causes of primary GN were focal segmental glomerulosclerosis (20.9%), mesangioproliferative GN (14.6%), IgA nephropathy (8.9%) and minimal change disease (13%). Lupus nephritis (6%) and Henoch-Schönlein nephritis (4%) were the most common secondary glomerular diseases. Conclusions: The epidemiology of glomerular disease in our single-center report is similar to that in data from adjacent Croatia and Greece. Focal segmental glomerulosclerosis was the dominant histopathological finding, followed by mesangioproliferative GN and IgA nephropathy. © 2012 Società Italiana di Nefrologia.ChildrenEpidemiologyFocal segmental glomerulosclerosisGlomerular diseaseNephrotic syndromePercutaneous renal biopsy