Vučević, Danijela (55881342600)Danijela (55881342600)VučevićHrnčić, Dragan (13907639700)Dragan (13907639700)HrnčićRadosavljević, Tatjana (6603466847)Tatjana (6603466847)RadosavljevićMladenović, Dušan (36764372200)Dušan (36764372200)MladenovićRašić-Marković, Aleksandra (23480382100)Aleksandra (23480382100)Rašić-MarkovićLončar-Stevanović, Helena (6602509768)Helena (6602509768)Lončar-StevanovićDjurić, Dragan (36016317400)Dragan (36016317400)DjurićMacut, Djuro (35557111400)Djuro (35557111400)MacutŠušić, Veselinka (7003269321)Veselinka (7003269321)ŠušićStanojlović, Olivera (6602159151)Olivera (6602159151)Stanojlović2025-07-022025-07-022008https://doi.org/10.1139/Y08-010https://www.scopus.com/inward/record.uri?eid=2-s2.0-42149154827&doi=10.1139%2fY08-010&partnerID=40&md5=0b18309306200a5e9e09eb0da6e7a0e1https://remedy.med.bg.ac.rs/handle/123456789/14305We report a study on the relation between open-field behavior and electroencephalographic (EEG) changes during lindane-induced seizures in 2-month-old adult male Wistar rats. For chronic EEG recordings and power spectra analysis, 3 electrodes were implanted into the skull. Three groups of animals, (i) saline-injected control (n = 6), (ii) DMSO-treated (n = 6), and (iii) lindane intraperitoneally administered: L4 (4 mg/kg,n = 10), L 6 (6 mg/kg, n = 11), and L8 (8 mg/kg, n = 11), were observed for 30 min for the occurrence of convulsive behavior. It was assessed by incidence of motor seizures, and seizure severity grade was determined by a descriptive rating scale (0, no response; 1, head nodding, lower jaw twitching; 2, myoclonic body jerks, bilateral forelimb clonus with full rearing; 3, progression to generalized clonic convulsions followed by tonic extension of fore and hind limbs and tail; 4, status epilepticus). EEG signal and spectral analyses were suitable to describe the dynamics of complex behavioral responses. Incidence and severity of epileptic manifestations, recorded as high voltage spike-wave complexes, polyspikes, sleep-like patterns in EEG, and power spectra changes, were greater in lindane-treated groups in a dose-dependent manner compared with control or DMSO-treated groups. Our results suggest good correlation between lindane-induced epileptiform activity and behavioral changes. © 2008 NRC.EEGLindanePower spectraRatsSeizure grades