Oluić, Branislav (57201078229)Branislav (57201078229)OluićJadrijevic, Stipislav (6507816941)Stipislav (6507816941)JadrijevicPantic, Ivana (57223613349)Ivana (57223613349)PanticDragasevic, Sanja (56505490700)Sanja (56505490700)DragasevicPopovic, Dusan (37028828200)Dusan (37028828200)PopovicLalosevic, Milica Stojkovic (57218133245)Milica Stojkovic (57218133245)LalosevicVlaisavljevic, Zeljko (56461417200)Zeljko (56461417200)VlaisavljevicAbdi, Alireza (56845014200)Alireza (56845014200)AbdiMilovanovic, Tamara (55695651200)Tamara (55695651200)Milovanovic2025-07-022025-07-022022https://doi.org/10.1891/JDNP-2021-0026https://www.scopus.com/inward/record.uri?eid=2-s2.0-85141473620&doi=10.1891%2fJDNP-2021-0026&partnerID=40&md5=4e38f0d66649e78f390001733457b61ahttps://remedy.med.bg.ac.rs/handle/123456789/11993Background: Liver transplantation (LT) is the most effective treatment for patients with end-stage liver disease, which dramatically effects patient’s quality of life (QoL). The aim of this study was to evaluate the impact of socio-demographic and clinical factors on different QoL domains of patients who underwent orthotopic LT. Methods: A cross-sectional study included a total of 43 patients who underwent a LT from 2013 to 2018. Socio-demographic and clinical data were recorded in each patient.The QoL was estimated using two validated questionnaires: 36-Item Short Form Health Survey (SF-36) and Chronic Liver Disease Questionnaire (CLDQ). Results: Male patients obtained significantly higher scores than women, in the domains of general health perception (83.2 ± 16.3 vs. 71.0 ± 18.4; t = 2.229, p =.031) and physical component summary (69.0 ± 7.2 vs. 62.0 ± 11.4; t = 2.451, p =.019). There were no significant differences in other domains of SF-36 and CLDQ. Etiology of the underlying liver disease and the presence of post-transplant complications showed no effect on score values of SF-36 and CDLQ domains (p <.05). Time from LT showed negative medium correlation with role limitations due to physical health problems (S = −0.417, p =.005), while no other significant correlations were noted in other items of SF-36 and CLDQ. Conclusions: Men had higher scores in the domain of general health perception and physical component summary following LT than women. With the increase in time from LT, patients experience a decrease in limitations due to physical health problems. The audit and improvement of QoL is an essential part of the individualized long-term health-care approach to LT patients. © 2022 Springer Publishing Company.liver diseaseliver transplantationquality of lifequestionnaire