Radovanovic, Slavica (24492602300)Slavica (24492602300)RadovanovicSavic-Radojevic, Ana (16246037100)Ana (16246037100)Savic-RadojevicPekmezovic, Tatjana (57225343013)Tatjana (57225343013)PekmezovicMarkovic, Olivera (57205699382)Olivera (57205699382)MarkovicMemon, Lidija (13007465900)Lidija (13007465900)MemonJelic, Svetlana (57206488672)Svetlana (57206488672)JelicSimic, Dragan (57212512386)Dragan (57212512386)SimicRadic, Tanja (35275858300)Tanja (35275858300)RadicPljesa-Ercegovac, Marija (16644038900)Marija (16644038900)Pljesa-ErcegovacSimic, Tatjana (6602094386)Tatjana (6602094386)Simic2025-06-122025-06-122014https://doi.org/10.1016/j.recesp.2013.11.017https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904767221&doi=10.1016%2fj.recesp.2013.11.017&partnerID=40&md5=1bd28461b2a5c62a2cac1b50c6d003bahttps://remedy.med.bg.ac.rs/handle/123456789/8797Introduction and objectives Uric acid and gamma-glutamyl transferase are prognostic indicators in chronic heart failure. Nevertheless, the mechanism underlying the association between uric acid, gamma-glutamyl transferase, and chronic heart failure progression and prognosis remains largely unknown. Methods The association of uric acid and gamma-glutamyl transferase with flow-mediated dilation and echocardiographic indices of cardiac remodeling was addressed in 120 patients with chronic ischemic heart failure. To determine the independent contribution of uric acid and gamma-glutamyl transferase to the flow-mediated dilation and echocardiographic indices of remodeling, a series of multiple linear regression models, based on traditional and nontraditional risk factors impacting upon these parameters, were constructed. Results Uric acid, but not gamma-glutamyl transferase, was an independent predictor of flow-mediated dilation. Uric acid was associated with all the echocardiographic indices of left ventricular dysfunction tested in 3 multiple-regression models. Uric acid correlated with left ventricular end-systolic diameter, left ventricular end-diastolic diameter, left ventricular end-systolic volume, and left ventricular end-diastolic volume (r = 0.337; r = 0.340; r = 0.321; r = 0.294; P =.001, respectively). Gamma-glutamyl transferase was an independent predictor of left ventricular end-systolic volume and left ventricular end-diastolic volume, after adjustment for all variables. Gamma-glutamyl transferase correlated with left ventricular end-diastolic diameter, left ventricular end-diastolic diameter, left ventricular end-systolic volume, and left ventricular end-diastolic volume (r = 0.238, P =.009; r = 0.219, P =.016; r = 0.359, P <.001; r = 0.369, P =.001, respectively). Conclusions Serum uric acid and gamma-glutamyl transferase levels are associated with left ventricular remodeling in patients with chronic ischemic heart failure. Full English text available from: www.revespcardiol.org/en. © 2013 Sociedad Española de Cardiología. Published by Elsevier España, S.L. All rights reserved.Chronic heart failureFlow mediated dilationGamma-glutamyl transferaseOxidative stressRemodelingUric acid