Dragašević-Mišković, Nataša T (59157743200)Nataša T (59157743200)Dragašević-MiškovićBobić, Vladislava (57188682247)Vladislava (57188682247)BobićKostić, Milutin (56567649800)Milutin (56567649800)KostićStanković, Iva (58775209600)Iva (58775209600)StankovićRadovanović, Saša (6604015284)Saša (6604015284)RadovanovićDimitrijević, Kosta (57219650171)Kosta (57219650171)DimitrijevićSvetel, Marina (6701477867)Marina (6701477867)SvetelPetrović, Igor (7004083314)Igor (7004083314)PetrovićĐurić-Jovičić, Milica (26633912900)Milica (26633912900)Đurić-Jovičić2025-06-122025-06-122021https://doi.org/10.1016/j.clineuro.2020.106324https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094571885&doi=10.1016%2fj.clineuro.2020.106324&partnerID=40&md5=ee9323a001239c250d96cd0edf6895a3https://remedy.med.bg.ac.rs/handle/123456789/4520Objective: The goal of this study was to analyze how depression associated with Parkinson's disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed. Patients and Methods: Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods. Results: Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients. Conclusions: Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task. Significance: Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients. © 2020 Elsevier B.V.DepressionDual-task paradigmGait analysisGait variabilityParkinson's disease