Cacciaguerra, Laura (57185733400)Laura (57185733400)CacciaguerraPagani, Elisabetta (7005421345)Elisabetta (7005421345)PaganiMesaros, Sharlota (7004307592)Sharlota (7004307592)MesarosDackovic, Jelena (19034069600)Jelena (19034069600)DackovicDujmovic-Basuroski, Irena (6701590899)Irena (6701590899)Dujmovic-BasuroskiDrulovic, Jelena (55886929900)Jelena (55886929900)DrulovicValsasina, Paola (6506051299)Paola (6506051299)ValsasinaFilippi, Massimo (7202268530)Massimo (7202268530)FilippiRocca, Maria Assunta (34973365100)Maria Assunta (34973365100)Rocca2025-07-022025-07-022019https://doi.org/10.1177/1352458518787347https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050695638&doi=10.1177%2f1352458518787347&partnerID=40&md5=87ec14f1a7f5bc74c80f7a5c2e5fac09https://remedy.med.bg.ac.rs/handle/123456789/12692Background: Different subregional patterns of hippocampal involvement have been observed in diverse multiple sclerosis (MS) phenotypes. Objective: To evaluate the occurrence of regional hippocampal variations in clinically isolated syndrome (CIS) patients, their relationships with focal white matter (WM) lesions, and their prognostic implications. Methods: Brain dual-echo and three-dimensional (3D) T1-weighted scans were acquired from 14 healthy controls and 36 CIS patients within 2 months from clinical onset and after 3, 12, and 24 months. Radial distance distribution was assessed using 3D parametric surface mesh models. A cognitive screening was also performed. Results: Patients showed clusters of reduced radial distance in the Cornu Ammonis 1 from month 3, progressively extending to the subiculum, negatively correlated with ipsilateral T2 and T1 lesion volume. Increased radial distance appeared in the right dentate gyrus after 3 (p < 0.05), 12, and 24 (p < 0.001) months, and in the left one after 3 and 24 months (p < 0.001), positively correlated with lesional measures. Hippocampal volume variations were more pronounced in patients converting to MS after 24 months and did not correlate with cognitive performance. Conclusion: Regional hippocampal changes occur in CIS, are more pronounced in patients converting to MS, and are modulated by focal WM lesions. © The Author(s), 2018.dentate gyrushippocampuslongitudinal analysisMRImultiple sclerosisShape analysis