Basta-Jovanovic, Gordana (6603093303)Gordana (6603093303)Basta-JovanovicGvozdenovic, Eleonora (14832449700)Eleonora (14832449700)GvozdenovicDimitrijević, Ivan (57207504419)Ivan (57207504419)DimitrijevićBrasanac, Dimitrije (6603393153)Dimitrije (6603393153)BrasanacJovanovic, Milena (56490840800)Milena (56490840800)JovanovicKalezić, Nevena (6602526969)Nevena (6602526969)KalezićBaralic, Ivana (24400806100)Ivana (24400806100)BaralicRadojevic-Skodric, Sanja (15726145200)Sanja (15726145200)Radojevic-SkodricArsic, Dejan (56901087900)Dejan (56901087900)Arsic2025-06-122025-06-122008https://doi.org/10.1080/15513810802028704https://www.scopus.com/inward/record.uri?eid=2-s2.0-45849147671&doi=10.1080%2f15513810802028704&partnerID=40&md5=d36cf2b8ab5cb19368f8063ec2239e59https://remedy.med.bg.ac.rs/handle/123456789/10683The aim of our study was to investigate the expression of γ-catenin in normal kidney and in Wilms' tumor by immunohistochemistry and to correlate the results with tumor stage, histological type, and prognostic group. We investigated 28 cases of Wilms' tumor, 2 Wilms' tumor metastases in lungs, and 1 specimen of normal renal tissue. Expression of γ-catenin was detected in 14 cases. There was a weak inverse relationship between γ-catenin expression and tumor stage. Expression of γ-catenin was detected in various histologic types of Wilms' tumor, but there was no statistically significant correlation, except in cases with diffuse anaplasia that were negative. In 2 metastatic cases and in the case of bilateral Wilms' tumor γ-catenin immunostaining was not observed Our findings suggest an absence of strong correlation between the loss of γ-catenin and unfavorable outcome. Copyright © Informa Healthcare USA, Inc.γ-cateninAdhesion moleculesHistological typePrognostic groupTumor stage