Protić, Dragana (18635502600)Dragana (18635502600)ProtićBaltić, Snežana (55812694500)Snežana (55812694500)BaltićStupar, Nada Vujasinović (36549315900)Nada Vujasinović (36549315900)StuparPavlov-Dolijanović, Slavica (8452470400)Slavica (8452470400)Pavlov-DolijanovićMugoša, Snežana (56311536000)Snežana (56311536000)MugošaTodorović, Zoran (7004371236)Zoran (7004371236)Todorović2025-06-122025-06-122014https://doi.org/10.2478/s11536-013-0313-zhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84905502077&doi=10.2478%2fs11536-013-0313-z&partnerID=40&md5=bf4b3a47e0ed2715693401709c6b6d6chttps://remedy.med.bg.ac.rs/handle/123456789/8737Statins might cause and/or aggravate the immune-mediated myositis in patients on long-term, stable treatment. We provide a case of polymyositis with an immunological background and gastrointestinal and urinary manifestations in patient on long-term, stable atorvastatin treatment for the past six years. The diagnose of polymyositis was established based on clinical symptoms and signs, electromyography and laboratory test results (elevated aspartate aminotransferase 279 U/L, reference range 0-40 U/L; alanine aminotransferase 198 U/L, 0-33 U/L; lactate dehydrogenase 2200 U/L, 103-227 U/L; creatine kinase 7820 U/L, 15-84 U/L; and positive antinuclear antibodies test, titer of 1:160, with suspect antisynthetase antibodies). Polymyositis was probably related to atorvastatin treatment (Naranjo score, 5). Other probable causes of the myositis were rejected. Coricosteroid therapy, methotrexate and supplementation with vitamin D did not improve the condition. The patient remained bedridden and died two months after the hospital discharge due to the acute myocardial infarction. © 2014 Versita and Springer-Verlag.AtorvastatinMyositisVitamin D