Association between Val158Met COMT, TNF-α -857 C>T, TNFR1 36 A>G, IL-1α 4845 G>T and IL-10 -1082 A>G polymorphisms and risk of early-onset preeclampsia and its complications; [Povezanost genskog polimorfizma Val158Met COMT, TNF-α -857 C>T, TNFR1 36 A>G, IL-1α 4845 G>T i IL-10 -1082 A>G sa rizikom od pojave rane preeklampsije i njenih komplikacija]

Krnjeta, Tijana (57190284217)Tijana (57190284217)KrnjetaMirković, Ljiljana (23474551800)Ljiljana (23474551800)MirkovićIgnjatović, Svetlana (55901270700)Svetlana (55901270700)IgnjatovićTomašević, Dragana (57190285757)Dragana (57190285757)TomaševićLukić, Jelena (57190276000)Jelena (57190276000)LukićTopalov, Drina (7801389703)Drina (7801389703)TopalovMajkić-Singh, Nada (56254156200)Nada (56254156200)Majkić-Singh2025-06-122025-06-122017https://doi.org/10.2298/VSP160329313Khttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85052673486&doi=10.2298%2fVSP160329313K&partnerID=40&md5=332968c073521a561db021dd2bfe6ae3https://remedy.med.bg.ac.rs/handle/123456789/7234Background/Aim. Preeclampsia (PE) belongs to the group of hypertensive disorders in pregnancy with the global average incidence of 2.16%. It is considered as one of the leading causes of maternal and neonatal morbidity and mortality worldwide. The goal of this study was to assess the potential association between Val158Met catechol-o-methyltransferase (COMT), tumor necrosis factor-alpha (TNF-α) -857 C>T, tumor necrosis factor receptor 1 (TNFR1) 36 A>G, interleukin-1alpha (IL-1α) 4845 G>T and interleukin-10 (IL-10) -1082 A>G polymorphisms and risk of early-onset preeclampsia (PE) and its complications. Methods. The study included 47 early-onset PE patients, which were grouped by disease severity and by size for gestational age and 47 control cases. The Val158Met polymorphism was genotyped by polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) analysis and inflammatory cytokine polymorphisms by the Sanger sequencing method. Results. The COMT Met allele as well as IL-1α T showed a protective role, decreasing the risk of early-onset PE after age and body mass index (BMI) adjustments. The detected interactions between the COMT Met and IL-10 A alleles, as well as between the COMT Met and TNF-α T alleles were insignificant after age and BMI adjustments. Conclusion. COMT and IL-1α may be used as candidate genes for early-onset PE and its severe form and small for gestational age (SGA) complications. © 2017, Inst. Sci. inf., Univ. Defence in Belgrade. All Rights Reserved.Comt proteinCytokinesGeneticHumanPolymorphismPre-eclampsiaAssociation between Val158Met COMT, TNF-α -857 C>T, TNFR1 36 A>G, IL-1α 4845 G>T and IL-10 -1082 A>G polymorphisms and risk of early-onset preeclampsia and its complications; [Povezanost genskog polimorfizma Val158Met COMT, TNF-α -857 C>T, TNFR1 36 A>G, IL-1α 4845 G>T i IL-10 -1082 A>G sa rizikom od pojave rane preeklampsije i njenih komplikacija]