Ercegovac, Marko (7006226257)Marko (7006226257)ErcegovacJović, Nebojsa (56367047200)Nebojsa (56367047200)JovićSimić, Tatjana (6602094386)Tatjana (6602094386)SimićBeslać-Bumbasirević, Ljiljana (6506489179)Ljiljana (6506489179)Beslać-BumbasirevićSokić, Dragoslav (35611592800)Dragoslav (35611592800)SokićSavić-Radojević, Ana (16246037100)Ana (16246037100)Savić-RadojevićMatić, Marija (58618962300)Marija (58618962300)MatićJovanović, Dejana (55419203900)Dejana (55419203900)JovanovićRistić, Aleksandar (7003835405)Aleksandar (7003835405)RistićDukić, Tatjana (36193753800)Tatjana (36193753800)DukićSuvakov, Sonja (36572404500)Sonja (36572404500)SuvakovCorić, Vesna (55584570400)Vesna (55584570400)CorićMimić-Oka, Jasmina (56022732500)Jasmina (56022732500)Mimić-OkaPljesa-Ercegovac, Marija (16644038900)Marija (16644038900)Pljesa-Ercegovac2025-06-122025-06-122013https://doi.org/10.2478/jomb-2013-0009https://www.scopus.com/inward/record.uri?eid=2-s2.0-84881516629&doi=10.2478%2fjomb-2013-0009&partnerID=40&md5=be511e3488c5df169bf2be1a10ab5829https://remedy.med.bg.ac.rs/handle/123456789/9150Background: To get more insight into the effects of the most widely used antiepileptic drugs (AEDs) on the pro oxi dant/ antioxidant balance in epi lep sy, a comparative analysis of the byproducts of oxidative damage and antioxidant de fense mechanisms was performed in patients with epilepsy treated with la mo trigine, carbamazepine and valproic acid. Methods: Byproducts of oxidative damage to proteins (reactive carbonyl derivatives, RCD and protein thiol groups, PSH), lipids (urinary isoprostanes, 8-epi-PGF2α) and DNA (urinary 8-hydroxy-2'-deoxyguanosine, 8-OHdG), as well as the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPX) were measured in 60 patients with newly diagnosed seizure (at illness onset and after 6 months of treatment with lamotrigine, carbamazepine or valproic acid) and in 20 healthy controls. Results: In patients with epilepsy, RCD, urinary 8-epi-PGF2α and 8-OHdG, together with SOD and GPX activities were significantly increased, while P-SH were only slightly decreased. After 6 months of treatment with AEDs, a decrease was observed in RCD, urinary 8-epi-PGF2α and 8-OHdG to values slightly higher or similar to the control, while P-SH remained unchanged. A decrease was also observed in SOD and GPX activities, although they remained significantly in creased compared to controls. Conclusions: The results of this study have shown that treatments with lamotrigine, carbamazepine and valproic acid affect the prooxidant/antioxidant balance in patients with epi lepsy.Antiepileptic drugsAntioxidant activityEpilepsyOxidative damageOxidative stress