Medjo, Biljana (33467923300)Biljana (33467923300)MedjoAtanaskovic-Markovic, Marina (6506020842)Marina (6506020842)Atanaskovic-MarkovicNikolic, Dimitrije (8279362600)Dimitrije (8279362600)NikolicRadic, Snezana (7006383145)Snezana (7006383145)RadicLazarevic, Ivana (23485928400)Ivana (23485928400)LazarevicCirkovic, Ivana (16309091000)Ivana (16309091000)CirkovicDjukic, Slobodanka (6603568490)Slobodanka (6603568490)Djukic2025-06-122025-06-122017https://doi.org/10.1093/tropej/fmw091https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029371242&doi=10.1093%2ftropej%2ffmw091&partnerID=40&md5=3b8642c6e70881833d8d2578f4a8aac1https://remedy.med.bg.ac.rs/handle/123456789/6951Background: Mycoplasma pneumoniae (MP) is a common cause of community-acquired pneumonia in children, and it has been associated with wheezing. The aim of this study was to examine the serum level of interleukin (IL)-4 and IL-10 in children with Mycoplasma pneumoniae pneumonia (MPP) and to analyse them in relation to the presence of wheezing. Methods: The study included 166 children with radiologically confirmed pneumonia. MP infection was confirmed by enzyme-linked immunosorbent assay (ELISA) serum MP-IgM and MP-IgG test and throat swab MP DNA with real-time polymerase chain reaction. Serum levels of IL-4 and IL-10 were measured using ELISA. Results: There was no significant difference in serum level of IL-4 between children with MPP and those with non-MPP. Among children with MPP, we found similar level of IL-4 regardless of the personal and family history of allergy and asthma or the presence of wheezing. A significantly higher level of IL-10 was found in children with MPP than in children with non-MPP (32.92±18.582 vs. 27.01±14.100 pg/ml, p =0.022). Furthermore, wheezing children with MPP had a significantly higher level of IL-10 than children with MPP without wheezing (43.75±26.644 vs. 27.50±10.211 pg/ml, p=0.027). Conclusion: Our results show significantly increased serum level of IL-10 in children with MPP, which was significantly higher in children with wheezing. These findings may suggest a role of IL-10 in the pathogenesis of MPP and in the occurrence of wheezing during acute MP infection. © The Author [2016]. Published by Oxford University Press. All rights reserved.ChildInterleukin-10Interleukin-4Mycoplasma pneumoniaePneumoniaWheezing