Veljančić, Ljubiša (6505943776)Ljubiša (6505943776)VeljančićPopović, Jovan (56715268600)Jovan (56715268600)PopovićRadović, Milan (57203260214)Milan (57203260214)RadovićAhrenholz, Peter (6603102920)Peter (6603102920)AhrenholzRies, Wolfgang (7005548390)Wolfgang (7005548390)RiesFrenken, Leon (7004599530)Leon (7004599530)FrenkenWojke, Ralf (9245790400)Ralf (9245790400)Wojke2025-07-022025-07-022011https://doi.org/10.5301/IJAO.2011.7746https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955648165&doi=10.5301%2fIJAO.2011.7746&partnerID=40&md5=5ed1cbfe1d0ee04a4c4c22a4debe02adhttps://remedy.med.bg.ac.rs/handle/123456789/14110Purpose: Intra-dialytic morbid events (IME; e.g. hypotension, cramps, headaches) are frequent complications during hemodialysis (HD), known to be associated with ultrafiltration-induced hypovolemia and body temperature changes. Feedback control of blood volume adjusts the ultrafiltration rate in order to keep the blood volume above the patient's individual limit; feedback control of blood temperature maintains the mean arterial blood temperature at the individual pre-dialytic level. Each of these methods reduces the frequency of IME. Methods: In a randomized clinical trial the simultaneous application of both feedback controls was investigated for the first time. In 15 weeks, each patient went through 3 study phases: an observational screening phase, a standard phase (STD), and a blood temperature- and blood volume-control phase (CTL). Patients with at least 5 sessions with IME out of 15 sessions in the screening phase were eligible for the study and randomized either into sequence STD-CTL or CTL-STD. Results: 26 patients completed the study according to protocol, and 778 HD treatments were analyzed. The general treatment parameters were similar in both study phases: treatment duration (STD: 244 min, CTL: 243 min, NS), pre-dialytic weight (STD: 72.3 kg, CTL: 72.2 kg, NS), and weight loss due to ultrafiltration (STD: 3.26 kg, CTL: 3.15 kg, NS). The proportion of HD treatments with IME was 32.8% during STD and 18.0% during CTL (p=0.024). Conclusions: The frequency of HD sessions with IME was significantly reduced by 45% compared to standard HD in this randomized clinical trial by use of individualized HD treatments with simultaneous feedback control of blood volume and blood temperature. © 2011 Wichtig Editore.Blood pressureBody temperatureComplicationsControlHemodialysisHypotensionPreventive measures