Micic, Dusan (37861889200)Dusan (37861889200)MicicLalic, Nebojsa (13702597500)Nebojsa (13702597500)LalicDjukic, Vladimir (57210262273)Vladimir (57210262273)DjukicStankovic, Sanja (7005216636)Sanja (7005216636)StankovicTrajkovic, Goran (9739203200)Goran (9739203200)TrajkovicOluic, Branislav (57201078229)Branislav (57201078229)OluicPolovina, Snezana (35071643300)Snezana (35071643300)Polovina2025-07-022025-07-022018https://doi.org/10.1515/jomb-2017-0043https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079128997&doi=10.1515%2fjomb-2017-0043&partnerID=40&md5=10c8cb3afd86747d907a4ea1b82913bahttps://remedy.med.bg.ac.rs/handle/123456789/12945Background: The aim of this study was to investigate the influence of IL-6, TNF-a and hs-CRP on insulin sensitivity during postoperative follow-up in patients with laparoscopic cholecystectomy (LC) or open hernia repair (OHR). Methods: 65 patients were studied: after laparoscopic cholecystectomy (LC; n=40) or open hernia repair (OHR; n=25). Glucose, insulin, hs-CRP, IL-6 and TNF-a were determined at day 0 (before the operation) and at days 1, 3 and 7 (after the operation). Results: There were no difference between LC and OHR groups concerning age, BMI, glucose, insulin, hs-CRP, IL-6 and TNF-a at day 0. hs-CRP increased at day 1, 3 and 7 vs. day 0 (p<0.0005), without difference between groups (p=0.561). IL-6 increased at day 1 and day 3 vs. day 0 (p<0.005). IL-6 was higher at day 1 in OHR group in comparison with LC group (p=0.044). There were no differences in TNF-a levels between LC and OHR groups (p=0.056). There was increase of HOMA-IR at day 1, 3 and 7 vs. day 0 (p<0.0005) in both groups. Significantly higher increase of HOMA-IR was in OHR group compared with LC group at day 1 (p=0.045). There was a positive correlation between hs-CRP and HOMA-IR (r=0.46; p=0.025) and between IL-6 and HOMA-IR at day 1 in OHR group (r=0.44; p=0.030). Conclusions: Significantly higher HOMA-IR was found in OHR group compared with LC. Positive correlation between hs-CRP and IL-6 with HOMA-IR in OHR group at day 1, indicate possible influence of this mediators on impairment of insulin sensitivity. © 2018 Society of Medical Biochemists of Serbia and Montenegro. All rights reserved.HOMA-IRHs-CRPIL-6SurgeryTNF-a