Dobrosavljevic, Aleksandar (57193973944)Aleksandar (57193973944)DobrosavljevicRakic, Snezana (11639224800)Snezana (11639224800)RakicMihajlovic, Sladjana (57191859364)Sladjana (57191859364)Mihajlovic2025-06-122025-06-122019https://doi.org/10.12669/pjms.35.4.145https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070771195&doi=10.12669%2fpjms.35.4.145&partnerID=40&md5=1fbe0401f7154f089d7d239ad4ae7482https://remedy.med.bg.ac.rs/handle/123456789/5480Objectives: The purpose of this study was to examine the potential impact of severe Ovarian hyper stimulation syndrome (OHSS) on the risk of preterm birth. Severe ovarian hyperstimulation syndrome is a serious complication in the methods of in vitro fertilization. The pathophysiology of this process is not clear enough and the treatment is symptomatic. Human chorionic gonadotropin (h-CG) is the most important known cause of this condition. Findings of other authors often do not match when it comes to complications that may occur in pregnancy. Methods: In the Gynecology and Obstetrics Clinic “Narodni Front” a case control study was conducted on 50 female patients with severe forms of OHSS in the period from January 2008 to March 2015. A control group was created based on age and it involved 59 patients with pregnancy achieved with IVF/ICSI during the same period, but in which OHSS did not occur. Results: Patients with the pregnancy complicated by OHSS, had a considerably higher rate of preterm labor, whether this was labor before gestation week 37 (56.0% vs. 30.5%) or before gestation week 34 (34.0% vs. 6.8%); significantly lower weight of newborns, as in the newborns with low body weight <2500g (45.6% vs. 25.0%) and specially in the newborn with very low body weight <1500 grams (19.1% vs. 3.8%), as well as preterm premature rupture of membranes (PPROM), (11.76% vs. 1.59%). Conclusions: Pregnancy achieved by the IVF/ICSI method in which severe form of OHSS has been developed could have an increased risk of preterm birth. © 2019, Professional Medical Publications. All rights reserved.IVF/ICSIOvarian hyper stimulation syndromePreterm birth