Lavrnic, D. (6602473221)D. (6602473221)LavrnicBasta, I. (8274374200)I. (8274374200)BastaRakocevic-Stojanovic, V. (6603893359)V. (6603893359)Rakocevic-StojanovicStevic, Z. (57204495472)Z. (57204495472)StevicPeric, S. (35750481700)S. (35750481700)PericNikolic, A. (19933823000)A. (19933823000)NikolicMarjanovic, I. (57201599576)I. (57201599576)MarjanovicPekmezovic, T. (7003989932)T. (7003989932)Pekmezovic2025-06-122025-06-122013https://doi.org/10.1159/000342777https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873048682&doi=10.1159%2f000342777&partnerID=40&md5=8626d5dfcc872f3fde370d02464e1429https://remedy.med.bg.ac.rs/handle/123456789/9232Background: The aim of this study was to analyze the prevalence and incidence of adult-onset myasthenia gravis (MG) in the Belgrade population from 1979 to 2008. Methods: Data on the number of MG patients and their basic demographic and clinical characteristics were collected from hospital records (1979-1992) and the Belgrade MG Registry (1993-2008). Incidence and prevalence were standardized by the direct method (using the world standard population). A time-trend analysis of MG incidence was performed using a linear regression model. Results: During the study period 562 cases (316 women, 246 men) were registered. On December 31st, 2008, the standardized prevalence (according to the world standard population) was 188.3/1,000,000 (women: 237.8/1,000,000; men: 139.4/1,000,000). The average annual standardized incidence rate was 13.3/1,000,000 (women: 14.1/1,000,000; men: 12.2/1,000,000). The incidence rates tended to increase significantly in both sexes during the study period (y = 3.299 + 14.363x, p = 0.002). Age-specific incidence rates for women demonstrated a bimodal pattern, with the first peak in the 20- to 29-year age group and the second one in the ≥70-year group. For both genders, an increase in age-specific incidence rates was registered for all age groups, although this was significant (p = 0.001) only for an MG onset of ≥60 years of age. Conclusions: The study confirms an increase in the incidence of MG in the area of Belgrade during the study period, especially for those with MG onset after 60 years of age. © 2013 S. Karger AG, Basel.IncidenceMyasthenia gravisPrevalenceTime trends