Saponjski, Jelena (57196482260)Jelena (57196482260)SaponjskiMacut, Djuro (35557111400)Djuro (35557111400)MacutPetrovic, Nebojsa (7006674561)Nebojsa (7006674561)PetrovicOgnjanovic, Sanja (14421284000)Sanja (14421284000)OgnjanovicPopovic, Bojana (36127992300)Bojana (36127992300)PopovicBukumiric, Zoran (36600111200)Zoran (36600111200)BukumiricSaranovic, Dragana Sobic (57234390300)Dragana Sobic (57234390300)Saranovic2025-06-122025-06-122023https://doi.org/10.5114/aoms/130996https://www.scopus.com/inward/record.uri?eid=2-s2.0-85176737788&doi=10.5114%2faoms%2f130996&partnerID=40&md5=87cea523eaf6a663074da6fbf75c667dhttps://remedy.med.bg.ac.rs/handle/123456789/3039Introduction: The aim was to assess the diagnostic value of 99mTc-Tektro-tyd scintigraphy (TCT) and positron emission tomography/computed tomography using F-18 fluorodeoxyglucose (18F-FDG PET/CT) in the detection and follow-up of neuroendocrine tumors (NETs), and their predictive value for disease progression. Material and methods: In this retrospective cohort, TCT and 18F-FDG PET/CT were performed in 90 patients (37 men, 53 women, mean age 52.7 ±15.1), with NET. Correlation of Ki67 and tumor grade versus Krenning score and SUVmax was assessed, Kaplan-Meier analysis was used for progression-free survival (PFS), and Cox regression analysis was performed to identify the association between progression-related factors and PFS. Results: Out of 90, true positive TCT was detected in 56 (62.2%) patients, true negative in 19 (21.1%), false positive in 4 (4.4%), false negative in 11 (12.2%), while 18F-FDG PET/CT was true positive in 69 (76.7%) patients, true negative in 10 (11.1%), false positive in 5 (5.5%), false negative in 6 (6.7%). Mean 18F-FDG PET/CT SUVmax was 6.8 ±6.2. Diagnostic sensitivity of TCT was 83.6%, specificity 82.6%, accuracy 83.3% vs. 18F-FDG PET/CT sensitivity was 92.0%, specificity 66.7%, accuracy 87.8%. A significant correlation between Ki67 and SUVmax was found in positive 18F-FDG PET/CT findings, unlike the correlation between Ki67 and Krenning score. Median PFS was 25 months (95% CI: 18.2–31.8), in 18F-FDG PET/CT positive patients 23 months (95% CI: 16.3–29.7) and 18F-FDG PET/CT negative 26 months (p = 0.279). Progression-free survival predictors were SUVmax and Krenning score. Conclusions: In our study, TCT and 18F-FDG PET/CT have high diagnostic accuracy in detection of NET. Higher Krenning score on TCT and SUVmax in positive 18F-FDG PET/CT findings are predictors of disease progression. 99mTc-Tek-trotyd scintigraphy and 18F-FDG PET/CT can be useful complementary tools in management of patients with NETs and in predicting patients’ outcome. Copyright © 2021 Termedia & Banach.