Paskaš, Svetlana (24512570500)Svetlana (24512570500)PaskašJanković, Jelena (55555671900)Jelena (55555671900)JankovićMarečko, Ilona (57210359065)Ilona (57210359065)MarečkoIšić Denčić, Tijana (13008078500)Tijana (13008078500)Išić DenčićTatić, Svetislav (6701763955)Svetislav (6701763955)TatićCvejić, Dubravka (7003808274)Dubravka (7003808274)CvejićSavin, Svetlana (35568292500)Svetlana (35568292500)Savin2025-06-122025-06-122014https://doi.org/10.1177/0194599813512781https://www.scopus.com/inward/record.uri?eid=2-s2.0-84893529790&doi=10.1177%2f0194599813512781&partnerID=40&md5=218f5142d0c322b4d5e8d40d058eb75dhttps://remedy.med.bg.ac.rs/handle/123456789/8575Objective. We aimed to investigate the role of caveolin-1 in papillary thyroid carcinoma pathogenesis. Study Design. Case series with chart review. Setting. Institute for the Application of Nuclear Energy. Subjects and Methods. We evaluated the expression of caveolin-1 in papillary thyroid carcinoma (PTC) by Western blot (WB) and compared the findings with immunohistochemical (IHC) expression of both epithelial and stromal caveolin-1 on the corresponding histological specimens. The results were related to clinicopathological features and BRAF mutation status. Results. Caveolin-1 expression was found in malignant thyroid epithelium and more abundantly in tumor stroma but varied in both compartments within and between PTC subtypes. Caveolin-1 expression in the epithelium was more intense in classical PTC than in the other histological types. On the contrary, stromal caveolin-1 expression was stronger in the follicular, solid, and trabecular PTC variants than in classical PTC. Trends for down-regulation of caveolin-1 expression in epithelium and up-regulation in stroma from the classical via follicular to the solid variant were observed. The relation of WB and IHC results with clinicopathological parameters showed lower caveolin-1 tissue content in BRAF mutated tumors (P <.05), a positive correlation of epithelial caveolin-1 expression with lymph node metastasis (P <.05), and a negative association of stromal caveolin-1 expression with the degree of neoplastic infiltration and BRAF status. Conclusion. Altered expression of caveolin-1 in the thyroid epithelial and stromal compartments may be involved in the pathogenesis of PTC. The potential clinical significance of caveolin-1 expression, as well as its relation to BRAF mutation status, deserves further investigation. © 2013 American Academy of Otolaryngology - Head and Neck Surgery Foundation.BRAFcaveolin-1immunohistochemistrypapillary thyroid cancer