Rakocevic-stojanovic, Vidosava (6603893359)Vidosava (6603893359)Rakocevic-stojanovicPeric, Stojan (35750481700)Stojan (35750481700)PericSavic-pavicevic, Dusanka (18435454500)Dusanka (18435454500)Savic-pavicevicPesovic, Jovan (15725996300)Jovan (15725996300)PesovicMesaros, Sarlota (7004307592)Sarlota (7004307592)MesarosLavrnic, Dragana (6602473221)Dragana (6602473221)LavrnicJovanovic, Zagorka (7006487114)Zagorka (7006487114)JovanovicPavlovic, Aleksandra (7003808508)Aleksandra (7003808508)Pavlovic2025-06-122025-06-122016https://doi.org/10.1002/mus.24927https://www.scopus.com/inward/record.uri?eid=2-s2.0-84963614529&doi=10.1002%2fmus.24927&partnerID=40&md5=e9c092b80540695968ce9deb2210821ehttps://remedy.med.bg.ac.rs/handle/123456789/7732Introduction: The aim of this study was to analyze transcranial sonography (TCS) findings in genetically confirmed myotonic dystrophy type 2 (DM2) patients. Methods: Forty DM2 patients and 38 gender- and age-matched healthy controls (HCs) underwent TCS through the pre-auricular acoustic bone window. Results: Substantia nigra hyperechogenicity was found in 20% of DM2 patients compared with 3% of HCs. Brainstem raphe (BR) hypoechogenicity was more common in DM2 patients compared with HCs (56% vs. 10%, P<0.01), and it was more common in patients with fatigue and excessive daytime sleepiness (P<0.05). Diameter of the third ventricle was increased in DM2 patients compared with HCs (5.8±1.7 vs. 5.1±1.0mm, P<0.05). Conclusions: Finding BR hypoechogenicity might have clinical implication because of the potential response to serotonin-reuptake inhibitors. TCS revealed alterations in brain structures previously not seen in MRI studies. © 2016 Wiley Periodicals, Inc.Brainstem rapheFatigueMyotonic dystrophy type 2SleepinessSubstantia nigraTranscranial sonography