Medenica, S. (33568078600)S. (33568078600)MedenicaRadojevic, N. (53871771600)N. (53871771600)RadojevicStojkovic, M. (7006722691)M. (7006722691)StojkovicNedeljkovic-Beleslin, B. (6701355427)B. (6701355427)Nedeljkovic-BeleslinSavic, S. (35328081800)S. (35328081800)SavicCiric, J. (6601995819)J. (6601995819)CiricTrbojevic, B. (6602073472)B. (6602073472)TrbojevicZarkovic, M. (7003498546)M. (7003498546)Zarkovic2025-06-122025-06-122015https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942279835&partnerID=40&md5=ddbe5d998797a90f14eace28fe07e237https://remedy.med.bg.ac.rs/handle/123456789/8401OBJECTIVE: Malignancies and autoimmune thyroid disease are still controversial, but recent studies prove that a long lasting thyroid disease may be linked with malignancy, e.g. papillary thyroid carcinoma in patients with Hashimoto thyroiditis. Having in mind that thyrotropin is a thyroid growth factor, the relationship between its serum values, as well as the levels of anti-peroxidase and anti-thyroglobulin antibodies and thyroid malignancy in patients with nodular thyroid goiter was examined. PATIENTS AND METHODS: Six-hundredthirty- seven medical records, which included the thyroid fine-needle aspiration cytology were retrospectively evaluated. Patients were grouped regarding the levels of thyrotropin, anti-peroxidase and anti-thyroglobulin antibodies (in or out of the reference ranges) and compared with cytology findings for establishing their prognostic potential for malignancy. RESULTS: Elevated serum thyrotropin (≥4.5 mIU/L) was found in 27.3% of patients with thyroid malignancy compared with 10.8% with benign and 16.1% with unspecified cytology finding (p < 0.01). In the group of patients with malignant cytology findings 7.0% of them had elevated anti-peroxidase antibodies level, and 1.4% had anti-peroxidase antibodies level in reference range. In the group of patients with malignant cytology findings 4.2% of them had elevated anti- thyroglobulin antibodies level, and 1.4% had anti-thyroglobulin antibodies level in reference range. CONCLUSIONS: In patients with elevated serum thyrotropin concentration and/or chronic thyroiditis the occurrence of thyroid malignancy is increased.Anti-peroxidase antibodiesAnti-thyroglobulin antibodiesNodular goiterThyroid autoimmunityThyrotropin