Ivanis, Sara (58505222200)Sara (58505222200)IvanisMarinkovic, Milan (56160715300)Milan (56160715300)MarinkovicJovanovic, Milan (57210477379)Milan (57210477379)JovanovicBuzejic, Matija (57220032907)Matija (57220032907)BuzejicMilinkovic, Marija (56584187000)Marija (56584187000)MilinkovicLoncar, Zlatibor (26426476500)Zlatibor (26426476500)LoncarZivaljevic, Vladan (6701787012)Vladan (6701787012)ZivaljevicRovcanin, Branislav (36697045000)Branislav (36697045000)Rovcanin2025-06-122025-06-122024https://doi.org/10.5812/ijem-156823https://www.scopus.com/inward/record.uri?eid=2-s2.0-85215430136&doi=10.5812%2fijem-156823&partnerID=40&md5=5ddf1bb4e8d22da372a11455861768f7https://remedy.med.bg.ac.rs/handle/123456789/952Introduction: Sertoli cell tumors are rare sex cord-stromal tumors, accounting for less than 1% of primary testicular tumors. They typically arise in the testes and ovaries, with other localizations being uncommon. We present the case of a Sertoli cell tumor in the adrenal gland, which, to our knowledge, is the first reported in the literature. Case Presentation: A 44-year-old male patient was admitted to the clinic for endocrine surgery for laparoscopic surgery of a right adrenal gland incidentaloma measuring 57 × 47 × 59 mm, discovered during a routine abdominal ultrasonography. The patient had a history of hypertension but no other comorbidities. Biochemical and physical examinations revealed no signs of hypercortisolism. Urinary metanephrine and normetanephrine levels were within normal limits. A right laparoscopic adrenalectomy was performed, and a 5 cm tumor was identified without evidence of locoregional invasion. Pathological examination confirmed a Sertoli cell tumor of the adrenal gland. Immunohistochemical analysis revealed positive staining for vimentin, steroidogenic factor 1 (SF1), and beta-catenin, while chromogranin A, hCG, PSA, and TTF1 were negative. The Ki-67 index was 3%. The patient was subsequently referred to a urologist, where testicular ultrasonography showed no abnormalities. There were no signs of recurrence during a 15-month follow-up period. Additionally, the patient’s biannual antihypertensive treatment was discontinued by a cardiologist 1.5 months post-surgery. Conclusions: Sertoli cell tumors are an exceptionally rare entity. To our knowledge, this is the first reported case of a primary Sertoli cell tumor originating in the adrenal gland. Given their potential for malignancy, regular follow-up and additional diagnostic evaluations may be necessary. Laparoscopic adrenalectomy appears to be a suitable definitive treatment for this condition. © 2024, Ivanis et al.Adrenal GlandCase ReportLaparoscopic SurgerySertoli Cell Tumor